日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

将人类肠道类器官整合到FDA的药物发现新方法论中

Patra, Debarun; Sayed, Ibrahim M; Mukherjee, Souhrid; Piplani, Honit; Habtezion, Aida; Rosen, Michael J; Wu, Jospeh C

Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis.

选择性抑制基质机械感受可抑制心肌纤维化

Cho Sangkyun, Rhee Siyeon, Madl Christopher M, Caudal Arianne, Thomas Dilip, Kim Hyeonyu, Kojic Ana, Shin Hye Sook, Mahajan Abhay, Jahng James W, Wang Xi, Thai Phung N, Paik David T, Wang Mingqiang, Mullen McKay, Baker Natalie M, Leitz Jeremy, Mukherjee Souhrid, Winn Virginia D, Woo Y Joseph, Blau Helen M, Wu Joseph C

ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity

ADMET-AI能够对药物引起的心脏毒性进行可解释的预测

Mukherjee, Souhrid; Swanson, Kyle; Walther, Parker; Shivnaraine, Rabindra V; Leitz, Jeremy; Pang, Paul D; Zou, James; Wu, Joseph C

Generation of induced pluripotent stem cell lines from patients with thoracic aortic aneurysm carrying the ACTA2 gene mutation

从携带ACTA2基因突变的胸主动脉瘤患者中生成诱导多能干细胞系

Liu, Tian-Ding; Sun, Shuai; Ren, Lu; Zhuge, Yan; Mukherjee, Souhrid; Liang, David H; Wu, Joseph C

Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target.

针对心脏纤维化的多尺度药物筛选发现 MD2 是一个治疗靶点

Zhang Hao, Thai Phung N, Shivnaraine Rabindra V, Ren Lu, Wu Xuekun, Siepe Dirk H, Liu Yu, Tu Chengyi, Shin Hye Sook, Caudal Arianne, Mukherjee Souhrid, Leitz Jeremy, Wen Wilson Tan Lek, Liu Wenqiang, Zhu Wenjuan, Chiamvimonvat Nipavan, Wu Joseph C

Generation of two induced pluripotent stem cell lines from patients with Williams syndrome.

从威廉姆斯综合征患者中生成两种诱导多能干细胞系

Dai Yuanyuan, Zhu Wenjuan, Flores Banuelos Amira G, Li Juana, Mukherjee Souhrid, Algaze Claudia, Wu Joseph C

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant

SGLT2抑制剂可改善与常见的ALDH2酒精潮红变异相关的内皮功能障碍

Guo, Hongchao; Yu, Xuan; Liu, Yu; Paik, David T; Justesen, Johanne Marie; Chandy, Mark; Jahng, James W S; Zhang, Tiejun; Wu, Weijun; Rwere, Freeborn; Zhao, Shane Rui; Pokhrel, Suman; Shivnaraine, Rabindra V; Mukherjee, Souhrid; Simon, Daniel J; Manhas, Amit; Zhang, Angela; Chen, Che-Hong; Rivas, Manuel A; Gross, Eric R; Mochly-Rosen, Daria; Wu, Joseph C

FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches

FDA现代化法案2.0:从动物模型过渡到基于人类细胞、类器官和人工智能/机器学习的方法

Zushin, Peter-James H; Mukherjee, Souhrid; Wu, Joseph C

The contribution of mosaicism to genetic diseases and de novo pathogenic variants

嵌合现象对遗传疾病和新生致病变异的贡献

Tinker, Rory J; Bastarache, Lisa; Ezell, Kimberly; Kobren, Shilpa Nadimpalli; Esteves, Cecilia; Rosenfeld, Jill A; Macnamara, Ellen F; Hamid, Rizwan; Cogan, Joy D; Rinker, David; Mukharjee, Souhrid; Glass, Ian; Dipple, Katrina; Phillips, John A 3rd

Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by de novo KCNC2 variants

个性化结构生物学揭示了由新生KCNC2变异引起的异质性癫痫表型的分子机制

Souhrid Mukherjee ,Thomas A Cassini ,Ningning Hu ,Tao Yang ,Bian Li ,Wangzhen Shen ,Christopher W Moth ,David C Rinker ,Jonathan H Sheehan ,Joy D Cogan ,Rizwan Hamid ,Robert L Macdonald ,Dan M Roden ,Jens Meiler ,Georg Kuenze ,John A Phillips ,John A Capra