日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors

双环脯氨酸的综合策略:在高效精氨酸酶抑制剂合成中的应用

Li, Derun; Zhang, Hongjun; Lyons, Thomas W; Lu, Min; Achab, Abdelghani; Pu, Qinglin; Childers, Matthew; Mitcheltree, Matthew J; Wang, Jialiang; Martinot, Theodore A; McMinn, Spencer E; Sloman, David L; Palani, Anandan; Beard, Adam; Nogle, Lisa; Gathiaka, Symon; Saurí, Josep; Kim, Hai-Young; Adpressa, Donovon; Spacciapoli, Peter; Miller, J Richard; Palte, Rachel L; Lesburg, Charles A; Cumming, Jared; Fischer, Christian

Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

氨基甲酸酯和N-嘧啶可减轻酰胺水解:基于结构的四氢喹啉IDO1抑制剂药物设计

Li, Derun; Deng, Yongqi; Achab, Abdelghani; Bharathan, Indu; Hopkins, Brett Andrew; Yu, Wensheng; Zhang, Hongjun; Sanyal, Sulagna; Pu, Qinglin; Zhou, Hua; Liu, Kun; Lim, Jongwon; Fradera, Xavier; Lesburg, Charles A; Lammens, Alfred; Martinot, Theodore A; Cohen, Ryan D; Doty, Amy C; Ferguson, Heidi; Nickbarg, Elliott B; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Abeywickrema, Pravien; Andrews, Christine; Chamberlin, Chad; Mabrouk, Omar; Curran, Patrick; Richards, Matthew; Saradjian, Peter; Miller, J Richard; Knemeyer, Ian; Otte, Karin M; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

基于结构的脯氨酸衍生精氨酸酶抑制剂的发现及其在免疫肿瘤学中提高的口服生物利用度

Lu, Min; Zhang, Hongjun; Li, Derun; Childers, Matthew; Pu, Qinglin; Palte, Rachel L; Gathiaka, Symon; Lyons, Thomas W; Palani, Anandan; Fan, Peter W; Spacciapoli, Peter; Miller, J Richard; Cho, Hyelim; Cheng, Mangeng; Chakravarthy, Kalyan; O'Neil, Jennifer; Eangoor, Padmanabhan; Beard, Adam; Kim, Hai-Young; Saurí, Josep; Gunaydin, Hakan; Sloman, David L; Siliphaivanh, Phieng; Cumming, Jared; Fischer, Christian

Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)

策略性地将极性引入血红素置换抑制剂中,以抑制吲哚胺-2,3-双加氧酶-1 (IDO1)

White, Catherine; McGowan, Meredeth A; Zhou, Hua; Sciammetta, Nunzio; Fradera, Xavier; Lim, Jongwon; Joshi, Elizabeth M; Andrews, Christine; Nickbarg, Elliott B; Cowley, Phillip; Trewick, Sarah; Augustin, Martin; von Köenig, Konstanze; Lesburg, Charles A; Otte, Karin; Knemeyer, Ian; Woo, Hyun; Yu, Wensheng; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Curran, Patrick; Heo, Mee Ra; Abeywickrema, Pravien; Miller, J Richard; Bennett, David Jonathan; Han, Yongxin

A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit

脑渗透性突变型IDH1抑制剂可延长体内生存时间

Johnny Kopinja, Raquel S Sevilla, Diane Levitan, David Dai, Amy Vanko, Edward Spooner, Chris Ware, Robert Forget, Kun Hu, Astrid Kral, Peter Spacciapoli, Richard Kennan, Lata Jayaraman, Vincenzo Pucci, Samanthi Perera, Weisheng Zhang, Christian Fischer, Michael H Lam

Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors

非ATP竞争性MK2(MAPKAPK2)抑制剂的发现和先导化合物优化

Huang, Xiaohua; Shipps, Gerald W Jr; Cheng, Cliff C; Spacciapoli, Peter; Zhang, Xingmin; McCoy, Mark A; Wyss, Daniel F; Yang, Xianshu; Achab, Abdelghani; Soucy, Kyle; Montavon, Donna K; Murphy, Denise M; Whitehurst, Charles E

Photoactive porphyrin derivative with broad-spectrum activity against oral pathogens In vitro

体外实验表明,一种具有广谱抗菌活性的光敏卟啉衍生物可有效对抗口腔病原体。

Rovaldi, C R; Pievsky, A; Sole, N A; Friden, P M; Rothstein, D M; Spacciapoli, P