日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现:一种口服有效的 DHX9 变构抑制剂

Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann

Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020:硅原子取代的战术应用

Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W

Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na(V)1.7 inhibitors

哌嗪酰胺类化合物作为选择性、状态依赖性Na(V)1.7抑制剂的发现和先导化合物评估

Sparling, Brian A; Yi, S; Able, J; Bregman, H; DiMauro, Erin F; Foti, R S; Gao, H; Guzman-Perez, A; Huang, H; Jarosh, M; Kornecook, T; Ligutti, J; Milgram, B C; Moyer, B D; Youngblood, B; Yu, V L; Weiss, M M

Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling towards the synthesis of (-)-cyatha-3,12-diene

利用镍(0)催化的烯炔-环氧化物还原偶联反应合成(-)-cyatha-3,12-二烯

Sparling, Brian A; Simpson, Graham L; Jamison, Timothy F

SmI2-promoted Reformatsky-type coupling reactions in exceptionally hindered contexts

在极度受限的条件下,SmI2促进的Reformatsky型偶联反应

Sparling, Brian A; Moslin, Ryan M; Jamison, Timothy F