日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Garcia Sanchez, Mariana; Kim, Ho Min; Vázquez Torres, Susana; Chan, Sidney; Sun, Shirley M; Spear, Timothy T; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers.

一种以吡咯并苯二氮卓类药物为有效载荷的人源化间变性淋巴瘤激酶(ALK)靶向抗体药物偶联物,在表达ALK的癌症中显示出疗效

Guerra Alberto D, Matkar Smita, Acholla Christina, Casey Colleen, Li Grant, Mazzeschi Martina, Patel Khushbu, Krytska Kateryna, Chen Chuan, Balyasny Skye, Kalna Joshua, Kamitsuka Paul, Gerelus Mark, Polkosnik Grace, Groff David, Mukherje Apratim, Adams Cynthia, Witek Gabriela, Hamilton Amber K, Martinez Daniel, Pogoriler Jennifer, Spear Timothy T, Li Yimei, Jung Piotr, Alvarado Diego, Lauriola Mattia, Maris John M, Wolpaw Adam J, Bosse Kristopher R, Dimitrov Dimiter, Mir Mustafa, Jelev Dontcho V, Mossé Yael P

D3-GPC2-Directed CAR T Cells Are Safe and Efficacious in Preclinical Models of Neuroblastoma and Small Cell Lung Cancer.

D3-GPC2 靶向 CAR T 细胞在神经母细胞瘤和小细胞肺癌的临床前模型中安全有效。

Giudice Anna Maria, Matlaga Stephanie, Roth Sydney L, Gladney Whitney, Groff David, Hofmann Ted J, McDaid Kendra S, Pascual-Pasto Guillem, McIntyre Brendan, Zecchino Vincent, Martinez Dan, Spear Timothy T, Wolpaw Adam J, Assenmacher Charles-Antoine, Radaelli Enrico, Pogoriler Jenny, Pawel Bruce, Barrett David, Grupp Stephan A, Maris John M, Bosse Kristopher R

Comparative exploration of multidimensional flow cytometry software: a model approach evaluating T cell polyfunctional behavior

多维流式细胞术软件的比较研究:一种评估T细胞多功能行为的模型方法

Spear, Timothy T; Nishimura, Michael I; Simms, Patricia E

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability

丙型肝炎病毒交叉反应性TCR基因修饰的T细胞:一种针对基因组不稳定性疾病的免疫疗法模型

Spear, Timothy T; Riley, Timothy P; Lyons, Gretchen E; Callender, Glenda G; Roszkowski, Jeffrey J; Wang, Yuan; Simms, Patricia E; Scurti, Gina M; Foley, Kendra C; Murray, David C; Hellman, Lance M; McMahan, Rachel H; Iwashima, Makio; Garrett-Mayer, Elizabeth; Rosen, Hugo R; Baker, Brian M; Nishimura, Michael I

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes

基于差示扫描荧光法的肽-MHC复合物热稳定性和动力学稳定性评估

Hellman, Lance M; Yin, Liusong; Wang, Yuan; Blevins, Sydney J; Riley, Timothy P; Belden, Orrin S; Spear, Timothy T; Nishimura, Michael I; Stern, Lawrence J; Baker, Brian M