日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt.

使用小分子稳定剂rezatapopt靶向p53癌症突变体Y220C、Y220N和Y220S。

Mavridi Danai, Funk Julianne S, Balourdas Dimitrios-Ilias, Krämer Andreas, Khan Tareque Raysa, Timofeev Oleg, Spencer John, Stiewe Thorsten, Joerger Andreas C

The dihydropyridine LA1011 modulates multiple Hsp90-co-chaperone interactions relevant to Alzheimer's disease

二氢吡啶类化合物LA1011可调节多种与阿尔茨海默病相关的Hsp90-辅助伴侣蛋白相互作用

Jeanne, Xavier; Oberoi, Jasmeen; Roe, Mark S; Baud, Matthias; Spencer, John; Torok, Zsolt; Vigh, Laszlo; Prodromou, Chrisostomos

Interleukin-6 Limits Host Susceptibility to Urinary Tract Infection by Promoting Urothelial Expulsion of Intracellular Bacteria

白细胞介素-6通过促进尿路上皮细胞排出细胞内细菌来降低宿主对尿路感染的易感性

Gupta, Sudipti; Rajak, Shradha; Cortado, Hanna; Becknell, Brian; Spencer, John David; Ching, Christina Barbara

Urinary Antimicrobial Peptides and Cytokines as Biomarkers for Recurrent Urinary Tract Infection in Children and Adolescents

尿液抗菌肽和细胞因子作为儿童和青少年复发性尿路感染的生物标志物

Yepes, Guillermo; Tang, Hancong Chloe; Holdsworth, Natalie; Salamon, Kristin; Schwartz, Laura; Ching, Christina; Rust, Steve; Spencer, John David

Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography

结合位点活性化合物纯化(B-SPA)结合多步阵列合成和高通量晶体学,可实现片段先导化合物的高效大规模筛选。

Grosjean, Harold; Aimon, Anthony; Hassell-Hart, Storm; Thompson, Warren; Koekemoer, Lizbé; Bennett, James; Bradley, Anthony; Anderson, Cameron; Wild, Conor; Bradshaw, William J; FitzGerald, Edward A; Krojer, Tobias; Fedorov, Oleg; Biggin, Philip C; Spencer, John; von Delft, Frank

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.

B55α和Greatwall表达水平之间的平衡可以预测癌细胞对Greatwall抑制剂的敏感性

Zach Róbert, Annis Michael, Martin-Guerrero Sandra M, Alatawi Abdulrahman, Chia Kim Hou, Meredith Megan, Osborn Kay, Peter Nisha, Pearce William, Booth Jessica, Rajasekaran Mohan, Dias Samantha, Coleman-Evans Lily, Foster William R, Harper Jon A, Herbert Alex D, Tighe Catherine, Reuillon Tristan, West Ryan, Busby Oliver, Burdova Kamila, Crepin Damien, Ortoll Sergi, Vaeteewoottacharn Kulthida, Dejsuphong Donniphat, Spencer John, Patel Hitesh, Le Grand Darren, Hunt Thomas A, Andrews David M, Yamano Hiroyuki, Cutillas Pedro R, Oliver Antony W, Ward Simon E, Hochegger Helfrid

NASA'S Lucy Mission to Trojan Asteroids: Unraveling the History of the Outer Solar System

NASA的露西号特洛伊小行星探测任务:揭开外太阳系的历史

Levison, Harold F; Marchi, Simone; Noll, Keith S; Spencer, John R; Olkin, Catherine B; Statler, Thomas S

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

基于 ISOX-DUAL 的结构导向降解剂设计:针对 BRD4 和 CBP/EP300 的降解剂崩溃案例

Edmonds Anthony K, Balourdas Dimitrios-Ilias, Marsh Graham P, Felix Robert, Brasher Bradley, Cooper Jeff, Graber-Feesl Cari, Kollareddy Madhu, Malik Karim, Stewart Helen, Chevassut Timothy J T, Lineham Ella, Morley Simon, Fedorov Oleg, Bennett James, Rajasekaran Mohan B, Ojeda Samuel, Harrison Drew A, Ott Christopher J, Joerger Andreas C, Maple Hannah J, Spencer John

Functional Raman Probes for Detecting Enzyme Activities Based on Aggregation Control

基于聚集控制的功能性拉曼探针用于检测酶活性

Okinaka, Momoko; Kawatani, Minoru; Fujioka, Hiroyoshi; Spratt, Spencer John; Ito, Hiroki; Misawa, Yoshihiro; Otake, Reika; Ishikawa, Aoi; Kojima, Ryosuke; Urano, Yasuteru; Ozeki, Yasuyuki; Kamiya, Mako

Prevalence and impact of abnormal blood pressure on left ventricular hypertrophy in adolescents with congenital heart disease

异常血压对先天性心脏病青少年左心室肥厚的患病率和影响

Walsh, Aaron T; Hor, Kan N; Eisner, Mariah; Alvarado, Chance; Kallash, Mahmoud; Spencer, John David; Tran, Andrew H