日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanisms of resistance to trastuzumab deruxtecan in breast cancer elucidated by multi-omic molecular profiling

通过多组学分子谱分析阐明乳腺癌对曲妥珠单抗德鲁替康的耐药机制

Sledge, George W; Xiu, Joanne; Mahtani, Reshma L; Sandoval Leon, Ana C; Meric-Bernstam, Funda; Ribeiro, Jennifer R; Kulkarni, Ninad N; Rampa, Dileep R; Lee, Jangsoon; Ueno, Naoto T; Oberley, Matthew J; Radovich, Milan; Spetzler, David B

Validation of an AI-enabled exome/transcriptome liquid biopsy platform for early detection, MRD, disease monitoring, and therapy selection for solid tumors.

验证人工智能驱动的外显子组/转录组液体活检平台在实体瘤早期检测、微小残留病灶检测、疾病监测和治疗选择中的应用

Abraham J, Domenyuk V, Perdigones N, Klimov S, Antani S, Yoshino T, Heath E I, Lou E, Liu S V, Marshall J L, El-Deiry W S, Shields A F, Dietrich M F, Nakamura Y, Fujisawa T, Demetri G D, Barker A, Xiu J, Sacchetti D A, Stahl S, Hahn-Lowry R, Stark A, Swensen J, Poste G, Halbert D D, Oberley M, Radovich M, Sledge G W, Spetzler David B

GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction during Routine Tumor Profiling

GPSai:一种经临床验证的AI工具,用于常规肿瘤分析中组织来源的预测

Ghani, Hassan; Helmstetter, Anthony; Ribeiro, Jennifer R; Maney, Todd; Rock, Stephanie; Feldman, Rebecca A; Swensen, Jeff; Abdulla, Farah; Spetzler, David B; Florento, Elena; Vanderwalde, Ari M; Pittman, Patricia; Radovich, Milan; Hechtman, Jaclyn; Bales, Casey; Sledge, George W; George, Myra M; Bryant, David; Abraham, Jim P; Oberley, Matthew J

Health Disparities among Patients with Cancer Who Received Molecular Testing for Biomarker-Directed Therapy

接受生物标志物定向治疗的癌症患者分子检测中存在的健康差异

Heath, Elisabeth; Dyson, Gregory; Ribeiro, Jennifer R; Xiu, Joanne; Poorman, Kelsey; Mamdani, Hirva; Al-Hallak, Mohammed N; Shields, Anthony F; Elayoubi, Jailan A; Winer, Ira S; Cackowski, Frank C; Puckrein, Gary A; Lopes, Gilberto de Lima; Jones, Nathaniel; Hauke, Ralph J; Kareff, Samuel A; Radovich, Milan; Sledge, George W; Spetzler, David B; Vidal, Gregory A; Marshall, John L

Somatic 9p24.1 alterations in HPV(-) head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity

HPV阴性头颈部鳞状细胞癌中9p24.1的体细胞改变决定免疫微环境和抗PD-1检查点抑制剂的活性。

Zhao, Xin; Cohen, Ezra E W; William, William N Jr; Bianchi, Joy J; Abraham, Jim P; Magee, Daniel; Spetzler, David B; Gutkind, J Silvio; Alexandrov, Ludmil B; Cavenee, Webster K; Lippman, Scott M; Davoli, Teresa

Immune evasion in HPV(-) head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss

HPV(-)头颈部癌前病变向癌变转变过程中的免疫逃逸是由涉及9p染色体缺失的非整倍体转换驱动的。

William, William N Jr; Zhao, Xin; Bianchi, Joy J; Lin, Heather Y; Cheng, Pan; Lee, J Jack; Carter, Hannah; Alexandrov, Ludmil B; Abraham, Jim P; Spetzler, David B; Dubinett, Steven M; Cleveland, Don W; Cavenee, Webster; Davoli, Teresa; Lippman, Scott M

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies

对大量胶质母细胞瘤患者进行多平台分子谱分析,揭示了潜在的治疗策略

Xiu, Joanne; Piccioni, David; Juarez, Tiffany; Pingle, Sandeep C; Hu, Jethro; Rudnick, Jeremy; Fink, Karen; Spetzler, David B; Maney, Todd; Ghazalpour, Anatole; Bender, Ryan; Gatalica, Zoran; Reddy, Sandeep; Sanai, Nader; Idbaih, Ahmed; Glantz, Michael; Kesari, Santosh