Spies M Ashley相关文献与解析，生知库 | 链接生命科学的每一步

Honda Masayoshi, Razzaghi Mortezaali, Gaur Paras, Malacaria Eva, Marozzi Giorgia, Di Biagi Ludovica, Aiello Francesca Antonella, Paintsil Emeleeta A, Stanfield Andrew J, Deppe Bailey J, Gakhar Lokesh, Schnicker Nicholas J, Spies M Ashley, Pichierri Pietro, Spies Maria

RAD52

发表日期：2025

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Real Way to Target Gram-Negative Pathogens: Discovery of a Novel Helicobacter pylori Antibiotic Class

靶向革兰氏阴性病原体的有效方法：发现一类新型幽门螺杆菌抗生素

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00112

Propp, Jonah Pascal; Castor, Damien Oz; Spies, M Ashley

微生物学

发表日期：2025

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Renin and renin blockade have no role in complement activity.

肾素和肾素阻断剂对补体活性没有作用

期刊:Kidney International

影响因子:12.6

doi:10.1016/j.kint.2023.11.005

Zhang Yuzhou, Martin Bertha, Spies M Ashley, Roberts Sarah M, Nott Joel, Goodfellow Renee X, Nelson Angela F M, Blain Samantha J, Redondo Elena, Nester Carla M, Smith Richard J H

免疫/内分泌

发表日期：2024

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A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein

药物发现的动态目标：RAD52蛋白的结构活性关系及其多种基因组（去）稳定功能

期刊:DNA Repair

影响因子:2.7

doi:10.1016/j.dnarep.2022.103421

Bhat, Divya S; Spies, M Ashley; Spies, Maria

RAD52

发表日期：2022

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An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics

从原子层面理解谷氨酸消旋酶的变构抑制：天然激活动力学的减弱

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.201900642

Witkin, Katie R; Vance, Nicholas R; Caldwell, Colleen; Li, Quinn; Yu, Liping; Spies, M Ashley

发表日期：2020

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Elucidating the Catalytic Power of Glutamate Racemase by Investigating a Series of Covalent Inhibitors

通过研究一系列共价抑制剂阐明谷氨酸消旋酶的催化能力

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.201800592

Vance, Nicholas R; Witkin, Katie R; Rooney, Patrick W; Li, Yalan; Pope, Marshall; Spies, M Ashley

发表日期：2018

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Integrating Experimental and In Silico HTS in the Discovery of Inhibitors of Protein-Nucleic Acid Interactions

整合实验和计算机高通量筛选技术以发现蛋白质-核酸相互作用抑制剂

期刊:Methods in Enzymology

影响因子:

doi:10.1016/bs.mie.2017.11.036

Li, Quinn; Folly da Silva Constantino, Laura; Spies, M Ashley

发表日期：2018

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Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

Caspase-7的变构调控：一种基于片段的药物发现方法

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.201706959

Vance, Nicholas R; Gakhar, Lokesh; Spies, M Ashley

信号转导

发表日期：2017

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Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N-Hydroxybenzimidazoles

N-羟基苯并咪唑对铜绿假单胞菌ExsA DNA结合活性的抑制作用

期刊:Antimicrobial Agents and Chemotherapy

影响因子:4.5

doi:10.1128/AAC.02242-15

Marsden, Anne E; King, Jessica M; Spies, M Ashley; Kim, Oak K; Yahr, Timothy L

发表日期：2016

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Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level

一种新型谷氨酸消旋酶的生物合成：该酶含有位点特异性的7-羟基香豆素氨基酸，并在原子水平上揭示了其酶-配体混杂性。

期刊:ACS Central Science

影响因子:10.4

doi:10.1021/acscentsci.5b00211

Dean, Sondra F; Whalen, Katie L; Spies, M Ashley

发表日期：2015

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The RAD52 double-ring remodels replication forks restricting fork reversal.

RAD52 双环重塑复制叉，限制复制叉逆转

Real Way to Target Gram-Negative Pathogens: Discovery of a Novel Helicobacter pylori Antibiotic Class

靶向革兰氏阴性病原体的有效方法：发现一类新型幽门螺杆菌抗生素

Renin and renin blockade have no role in complement activity.

肾素和肾素阻断剂对补体活性没有作用

A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein

药物发现的动态目标：RAD52蛋白的结构活性关系及其多种基因组（去）稳定功能

An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics

从原子层面理解谷氨酸消旋酶的变构抑制：天然激活动力学的减弱

Elucidating the Catalytic Power of Glutamate Racemase by Investigating a Series of Covalent Inhibitors

通过研究一系列共价抑制剂阐明谷氨酸消旋酶的催化能力

Integrating Experimental and In Silico HTS in the Discovery of Inhibitors of Protein-Nucleic Acid Interactions

整合实验和计算机高通量筛选技术以发现蛋白质-核酸相互作用抑制剂

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

Caspase-7的变构调控：一种基于片段的药物发现方法

Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N-Hydroxybenzimidazoles

N-羟基苯并咪唑对铜绿假单胞菌ExsA DNA结合活性的抑制作用

Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level

一种新型谷氨酸消旋酶的生物合成：该酶含有位点特异性的7-羟基香豆素氨基酸，并在原子水平上揭示了其酶-配体混杂性。