日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy

辅酶Q头部基团中间体可以改善线粒体脑病

Shi, Guangbin; Miller, Claire; Kuno, Sota; Rey Hipolito, Alejandro G; El Nagar, Salsabiel; Riboldi, Giulietta M; Korn, Megan; Tran, Wyatt C; Wang, Zixuan; Ficaro, Lia; Lin, Tao; Spillier, Quentin; Gamallo-Lana, Begoña; Jones, Drew R; Snuderl, Matija; Song, Soomin C; Mar, Adam C; Joyner, Alexandra L; Sillitoe, Roy V; Banh, Robert S; Pacold, Michael E

Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies

揭示二聚体LDH同工酶的酶活性及其对变构抑制策略的影响

Nadal-Bufi, Ferran; Van Gysel, Mégane; Brustenga, Chiara; Savoyen, Perrine; Mathieu, Caroline; Gobert, Alexandre; Sonveaux, Pierre; Spillier, Quentin; Fillet, Marianne; Wouters, Johan; Frédérick, Raphaël

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

色氨酸耗竭通过增加 AHR 表达和 GCN2/LAT1 介导的犬尿氨酸摄取来增强 AHR 通路的敏感性,并增强调节性 T 淋巴细胞的诱导。

Marie Solvay # ,Pauline Holfelder # ,Simon Klaessens ,Luc Pilotte ,Vincent Stroobant ,Juliette Lamy ,Stefan Naulaerts ,Quentin Spillier ,Raphaël Frédérick ,Etienne De Plaen ,Christine Sers ,Christiane A Opitz # ,Benoit J Van den Eynde # ,Jingjing Zhu #

The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway

极性氧代谢组揭示 4-羟基甘醇酸 CoQ10 合成途径

Robert S Banh, Esther S Kim, Quentin Spillier, Douglas E Biancur, Keisuke Yamamoto, Albert S W Sohn, Guangbin Shi, Drew R Jones, Alec C Kimmelman, Michael E Pacold

Structure-Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)

α-酮硫酰胺作为磷酸甘油酸脱氢酶 (PHGDH) 抑制剂的构效关系 (SAR)

Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

抗酒精滥用药物双硫仑通过特定的半胱氨酸氧化破坏其活性四聚体形式来抑制人类 PHGDH

Quentin Spillier, Didier Vertommen, Séverine Ravez, Romain Marteau, Quentin Thémans, Cyril Corbet, Olivier Feron, Johan Wouters, Raphaël Frédérick

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH)

α-酮硫酰胺衍生物:一种检测磷酸甘油酸脱氢酶 (PHGDH) 的有前途的工具

Séverine Ravez, Cyril Corbet, Quentin Spillier, Alice Dutu, Anita D Robin, Edouard Mullarky, Lewis C Cantley, Olivier Feron, Raphaël Frédérick