日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer

负选择维持转移性结直肠癌中显著改变但总体稳定的核型

Cross, William C H; Nowinski, Salpie; Cresswell, George D; Mossner, Maximilian; Banerjee, Abhirup; Lu, Bingxin; Williams, Marc J; Vlachogiannis, Georgios; Gay, Laura J; Baker, Ann-Marie; Kimberley, Christopher; Whiting, Frederick J H; Belnoue-Davis, Hayley L; Martinez, Pierre; Traki, Maria; Walther, Viola; Smith, Kane; Fernandez-Mateos, Javier; Yara-Romero, Erika; Oliveira, Erica A; Milite, Salvatore; Caravagna, Giulio; James, Chela T; Elia, George; Berner, Alison; Ryan Choi, Chang-Ho; Ramagiri, Pradeep; Chauhan, Ritika; Matthews, Nik; Murphy, Jamie; Antoniou, Anthony; Clark, Susan K; Mitchison, Miriam; Chin Aleong, Jo-Anne; Domingo, Enric; Spiteri, Inmaculada; McDonald, Stuart A C; Shibata, Darryl; Laclé, Miangela M; Wang, Lai Mun; Moorghen, Morgan; Tomlinson, Ian P M; Novelli, Marco; Jansen, Marnix; Watson, Alan; Valeri, Nicola; Wright, Nicholas A; Bridgewater, John A; Rodriguez-Justo, Manuel; Barnes, Chris P; Kocher, Hemant M; Leedham, Simon J; Sottoriva, Andrea; Graham, Trevor A

Epigenetically driven and early immune evasion in colorectal cancer evolution

表观遗传驱动和早期免疫逃逸在结直肠癌演变中的作用

Lakatos, Eszter; Gunasri, Vinaya; Zapata, Luis; Househam, Jacob; Heide, Timon; Trahearn, Nicholas; Swinyard, Ottilie; Cisneros, Luis; Lynn, Claire; Mossner, Maximilian; Kimberley, Chris; Spiteri, Inmaculada; Cresswell, George D; Llibre-Palomar, Gerard; Mitchison, Miriam; Maley, Carlo C; Jansen, Marnix; Rodriguez-Justo, Manuel; Bridgewater, John; Baker, Ann-Marie; Sottoriva, Andrea; Graham, Trevor A

Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.

细胞可塑性的表观遗传性通过一对多的基因型到表型范式驱动癌症耐药性

Oliveira Erica A, Milite Salvatore, Fernandez-Mateos Javier, Cresswell George D, Yara-Romero Erika, Vlachogiannis Georgios, Chen Bingjie, James Chela T, Patruno Lucrezia, Ascolani Gianluca, Acar Ahmet, Heide Timon, Spiteri Inmaculada, Graudenzi Alex, Caravagna Giulio, Bertotti Andrea, Graham Trevor A, Magnani Luca, Valeri Nicola, Sottoriva Andrea

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

表观基因组和早期选择决定了结直肠癌的肿瘤免疫进化轨迹

Lakatos, Eszter; Gunasri, Vinaya; Zapata, Luis; Househam, Jacob; Heide, Timon; Trahearn, Nicholas; Swinyard, Ottilie; Cisneros, Luis; Lynn, Claire; Mossner, Maximilian; Kimberley, Chris; Spiteri, Inmaculada; Cresswell, George D; Llibre-Palomar, Gerard; Mitchison, Miriam; Maley, Carlo C; Jansen, Marnix; Rodriguez-Justo, Manuel; Bridgewater, John; Baker, Ann-Marie; Sottoriva, Andrea; Graham, Trevor A

Contribution of pks(+) E. coli mutations to colorectal carcinogenesis

pks(+)大肠杆菌突变对结直肠癌发生的贡献

Chen, Bingjie; Ramazzotti, Daniele; Heide, Timon; Spiteri, Inmaculada; Fernandez-Mateos, Javier; James, Chela; Magnani, Luca; Graham, Trevor A; Sottoriva, Andrea

Phenotypic plasticity and genetic control in colorectal cancer evolution

结直肠癌演化中的表型可塑性和遗传控制

Househam, Jacob; Heide, Timon; Cresswell, George D; Spiteri, Inmaculada; Kimberley, Chris; Zapata, Luis; Lynn, Claire; James, Chela; Mossner, Maximilian; Fernandez-Mateos, Javier; Vinceti, Alessandro; Baker, Ann-Marie; Gabbutt, Calum; Berner, Alison; Schmidt, Melissa; Chen, Bingjie; Lakatos, Eszter; Gunasri, Vinaya; Nichol, Daniel; Costa, Helena; Mitchinson, Miriam; Ramazzotti, Daniele; Werner, Benjamin; Iorio, Francesco; Jansen, Marnix; Caravagna, Giulio; Barnes, Chris P; Shibata, Darryl; Bridgewater, John; Rodriguez-Justo, Manuel; Magnani, Luca; Sottoriva, Andrea; Graham, Trevor A

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

利用遗传和表观遗传克隆追踪技术,将乳腺癌转移级联过程映射到ctDNA上。

Cresswell, George D; Nichol, Daniel; Spiteri, Inmaculada; Tari, Haider; Zapata, Luis; Heide, Timon; Maley, Carlo C; Magnani, Luca; Schiavon, Gaia; Ashworth, Alan; Barry, Peter; Sottoriva, Andrea

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

患者来源的类器官模型可用于模拟转移性胃肠道癌症的治疗反应

Vlachogiannis, Georgios; Hedayat, Somaieh; Vatsiou, Alexandra; Jamin, Yann; Fernández-Mateos, Javier; Khan, Khurum; Lampis, Andrea; Eason, Katherine; Huntingford, Ian; Burke, Rosemary; Rata, Mihaela; Koh, Dow-Mu; Tunariu, Nina; Collins, David; Hulkki-Wilson, Sanna; Ragulan, Chanthirika; Spiteri, Inmaculada; Moorcraft, Sing Yu; Chau, Ian; Rao, Sheela; Watkins, David; Fotiadis, Nicos; Bali, Maria; Darvish-Damavandi, Mahnaz; Lote, Hazel; Eltahir, Zakaria; Smyth, Elizabeth C; Begum, Ruwaida; Clarke, Paul A; Hahne, Jens C; Dowsett, Mitchell; de Bono, Johann; Workman, Paul; Sadanandam, Anguraj; Fassan, Matteo; Sansom, Owen J; Eccles, Suzanne; Starling, Naureen; Braconi, Chiara; Sottoriva, Andrea; Robinson, Simon P; Cunningham, David; Valeri, Nicola

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial

PROSPECT-C II期结直肠癌临床试验中,纵向液体活检和克隆演化数学建模预测治疗失败时间

Khan, Khurum H; Cunningham, David; Werner, Benjamin; Vlachogiannis, Georgios; Spiteri, Inmaculada; Heide, Timon; Mateos, Javier Fernandez; Vatsiou, Alexandra; Lampis, Andrea; Damavandi, Mahnaz Darvish; Lote, Hazel; Huntingford, Ian Said; Hedayat, Somaieh; Chau, Ian; Tunariu, Nina; Mentrasti, Giulia; Trevisani, Francesco; Rao, Sheela; Anandappa, Gayathri; Watkins, David; Starling, Naureen; Thomas, Janet; Peckitt, Clare; Khan, Nasir; Rugge, Massimo; Begum, Ruwaida; Hezelova, Blanka; Bryant, Annette; Jones, Thomas; Proszek, Paula; Fassan, Matteo; Hahne, Jens C; Hubank, Michael; Braconi, Chiara; Sottoriva, Andrea; Valeri, Nicola

Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping

唾液样本是血液样本之外的一种可行的DNA来源,可用于高通量基因分型。

Abraham, Jean E; Maranian, Mel J; Spiteri, Inmaculada; Russell, Roslin; Ingle, Susan; Luccarini, Craig; Earl, Helena M; Pharoah, Paul P D; Dunning, Alison M; Caldas, Carlos