日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hijacking the MDM2 E3 Ligase with Novel BRD4-Targeting Proteolysis-Targeting Chimeras in Pancreatic Cancer Cells

利用新型BRD4靶向蛋白水解靶向嵌合体劫持MDM2 E3连接酶治疗胰腺癌细胞

Ficu, Mihaela P; Niculescu-Duvaz, Dan; Aljarah, Mohammed; Kershaw, Christopher S; Springer, Caroline J

Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow

通过连续流反应中的施密特重排和光化学氧杂环丙烷重排实现双环均哌嗪的放大生产

Brown, Michael; Aljarah, Mohammed; Asiki, Hannah; Leung, Leo M H; Smithen, Deborah A; Miller, Natalie; Nemeth, Gabor; Davies, Lawrence; Niculescu-Duvaz, Dan; Zambon, Alfonso; Springer, Caroline

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.

2-氨基亚甲基-5-磺酰噻唑类赖氨酰氧化酶(LOX)和LOXL2抑制剂在延缓肿瘤生长方面显示出显著疗效

Smithen Deborah A, Leung Leo M H, Challinor Mairi, Lawrence Rae, Tang HaoRan, Niculescu-Duvaz Dan, Pearce Simon P, Mcleary Robert, Lopes Filipa, Aljarah Mohammed, Brown Michael, Johnson Louise, Thomson Graeme, Marais Richard, Springer Caroline

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma

能够打破悖论且同时靶向SRC的RAF抑制剂对耐药性BRAF突变型黑色素瘤有效。

Girotti, Maria Romina; Lopes, Filipa; Preece, Natasha; Niculescu-Duvaz, Dan; Zambon, Alfonso; Davies, Lawrence; Whittaker, Steven; Saturno, Grazia; Viros, Amaya; Pedersen, Malin; Suijkerbuijk, Bart M J M; Menard, Delphine; McLeary, Robert; Johnson, Louise; Fish, Laura; Ejiama, Sarah; Sanchez-Laorden, Berta; Hohloch, Juliane; Carragher, Neil; Macleod, Kenneth; Ashton, Garry; Marusiak, Anna A; Fusi, Alberto; Brognard, John; Frame, Margaret; Lorigan, Paul; Marais, Richard; Springer, Caroline

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance

利用化学交换饱和转移磁共振技术检测前药激活酶羧肽酶G2的活性

Jamin, Yann; Eykyn, Thomas R; Poon, Evon; Springer, Caroline J; Robinson, Simon P

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

接受 BRAF 抑制剂治疗的患者皮肤鳞状细胞癌中的 RAS 突变

Su, Fei; Viros, Amaya; Milagre, Carla; Trunzer, Kerstin; Bollag, Gideon; Spleiss, Olivia; Reis-Filho, Jorge S; Kong, Xiangju; Koya, Richard C; Flaherty, Keith T; Chapman, Paul B; Kim, Min Jung; Hayward, Robert; Martin, Matthew; Yang, Hong; Wang, Qiongqing; Hilton, Holly; Hang, Julie S; Noe, Johannes; Lambros, Maryou; Geyer, Felipe; Dhomen, Nathalie; Niculescu-Duvaz, Ion; Zambon, Alfonso; Niculescu-Duvaz, Dan; Preece, Natasha; Robert, Lídia; Otte, Nicholas J; Mok, Stephen; Kee, Damien; Ma, Yan; Zhang, Chao; Habets, Gaston; Burton, Elizabeth A; Wong, Bernice; Nguyen, Hoa; Kockx, Mark; Andries, Luc; Lestini, Brian; Nolop, Keith B; Lee, Richard J; Joe, Andrew K; Troy, James L; Gonzalez, Rene; Hutson, Thomas E; Puzanov, Igor; Chmielowski, Bartosz; Springer, Caroline J; McArthur, Grant A; Sosman, Jeffrey A; Lo, Roger S; Ribas, Antoni; Marais, Richard

Contrasting effects of sunitinib within in vivo models of metastasis.

舒尼替尼在体内转移模型中表现出的相反作用

Welti Jonathan C, Powles Thomas, Foo Shane, Gourlaouen Morgane, Preece Natasha, Foster Julie, Frentzas Sophia, Bird Demelza, Sharpe Kevin, van Weverwijk Antoinette, Robertson David, Soffe Julie, Erler Janine T, Pili Roberto, Springer Caroline J, Mather Stephen J, Reynolds Andrew R

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

具有咪唑或呋喃中心骨架的新型三环吡唑类BRAF抑制剂

Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M J M; Ménard, Delphine; Zambon, Alfonso; Nourry, Arnaud; Davies, Lawrence; Manne, Helen A; Friedlos, Frank; Ogilvie, Lesley; Hedley, Douglas; Takle, Andrew K; Wilson, David M; Pons, Jean-Francois; Coulter, Tom; Kirk, Ruth; Cantarino, Neus; Whittaker, Steven; Marais, Richard; Springer, Caroline J