日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hijacking the MDM2 E3 Ligase with Novel BRD4-Targeting Proteolysis-Targeting Chimeras in Pancreatic Cancer Cells

利用新型BRD4靶向蛋白水解靶向嵌合体劫持MDM2 E3连接酶治疗胰腺癌细胞

Ficu, Mihaela P; Niculescu-Duvaz, Dan; Aljarah, Mohammed; Kershaw, Christopher S; Springer, Caroline J

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance

利用化学交换饱和转移磁共振技术检测前药激活酶羧肽酶G2的活性

Jamin, Yann; Eykyn, Thomas R; Poon, Evon; Springer, Caroline J; Robinson, Simon P

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

接受 BRAF 抑制剂治疗的患者皮肤鳞状细胞癌中的 RAS 突变

Su, Fei; Viros, Amaya; Milagre, Carla; Trunzer, Kerstin; Bollag, Gideon; Spleiss, Olivia; Reis-Filho, Jorge S; Kong, Xiangju; Koya, Richard C; Flaherty, Keith T; Chapman, Paul B; Kim, Min Jung; Hayward, Robert; Martin, Matthew; Yang, Hong; Wang, Qiongqing; Hilton, Holly; Hang, Julie S; Noe, Johannes; Lambros, Maryou; Geyer, Felipe; Dhomen, Nathalie; Niculescu-Duvaz, Ion; Zambon, Alfonso; Niculescu-Duvaz, Dan; Preece, Natasha; Robert, Lídia; Otte, Nicholas J; Mok, Stephen; Kee, Damien; Ma, Yan; Zhang, Chao; Habets, Gaston; Burton, Elizabeth A; Wong, Bernice; Nguyen, Hoa; Kockx, Mark; Andries, Luc; Lestini, Brian; Nolop, Keith B; Lee, Richard J; Joe, Andrew K; Troy, James L; Gonzalez, Rene; Hutson, Thomas E; Puzanov, Igor; Chmielowski, Bartosz; Springer, Caroline J; McArthur, Grant A; Sosman, Jeffrey A; Lo, Roger S; Ribas, Antoni; Marais, Richard

Contrasting effects of sunitinib within in vivo models of metastasis.

舒尼替尼在体内转移模型中表现出的相反作用

Welti Jonathan C, Powles Thomas, Foo Shane, Gourlaouen Morgane, Preece Natasha, Foster Julie, Frentzas Sophia, Bird Demelza, Sharpe Kevin, van Weverwijk Antoinette, Robertson David, Soffe Julie, Erler Janine T, Pili Roberto, Springer Caroline J, Mather Stephen J, Reynolds Andrew R

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

具有咪唑或呋喃中心骨架的新型三环吡唑类BRAF抑制剂

Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M J M; Ménard, Delphine; Zambon, Alfonso; Nourry, Arnaud; Davies, Lawrence; Manne, Helen A; Friedlos, Frank; Ogilvie, Lesley; Hedley, Douglas; Takle, Andrew K; Wilson, David M; Pons, Jean-Francois; Coulter, Tom; Kirk, Ruth; Cantarino, Neus; Whittaker, Steven; Marais, Richard; Springer, Caroline J