日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

作者更正:缺氧诱导中性粒细胞祖细胞组蛋白剪切和H3K4me3丢失,导致中性粒细胞免疫功能长期受损。

Sanchez-Garcia, Manuel A; Sadiku, Pranvera; Ortmann, Brian M; Wit, Niek; Negishi, Yutaka; Coelho, Patricia; Zhang, Ailiang; Pednekar, Chinmayi; Howden, Andrew J M; Griffith, David M; Seear, Rachel; Kindrick, Jessica D; Mengede, Janine; Cooper, George; Morrison, Tyler; Watts, Emily R; Shimeld, Benjamin T; Reyes, Leila; Mirchandani, Ananda S; Arienti, Simone; Xu, Xiang; Thomson, Alexander; Brenes, Alejandro J; Turton, Helena A; Dowey, Rebecca; Hull, Rebecca C; Davidson-Smith, Hazel; McLaren, Amy; Deans, Andrew; Choudhury, Gourab; Doverman, Katherine; Hope, David; Vick, Oliver; Woodhead, Alastair; Petrie, Isla; Green, Suzanne; Rzechorzek, Nina M; Turtle, Lance; Openshaw, Peter J M; Semple, Malcolm G; Sproul, Duncan; Baillie, J Kenneth; Thompson, Alfred A R; Mole, David R; von Kriegsheim, Alex; Whyte, Moira K B; Mhlanga, Musa M; Nathan, James A; Walmsley, Sarah R

DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A.

DNMT1 的缺失导致 DNMT3A 对一部分晚期复制结构域进行过度甲基化。

Kafetzopoulos Ioannis, Taglini Francesca, Pasquier Moira, Davidson-Smith Hazel, Rodger Christine J, Puchades Gimeno Lucia, Malcolm Andrew A, Sproul Duncan

Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers

与复制相关的机制导致错配修复缺陷型癌症中 CpG > TpG 突变负荷增加。

Ward, Joseph C; Soriano, Ignacio; Thorn, Steve; Fernández-Tajes, Juan; Sherwood, Kitty; Gül, Güler; Scheffers, Joost; Frangou, Anna; Kinnersley, Ben; Kafetzopoulos, Ioannis; Sproul, Duncan; Galavotti, Sara; Palles, Claire; Gruber, Andreas J; Church, David N; Tomlinson, Ian

Discovery and Characterization of Uracil Derivatives Targeting the Set-and-Ring Domain of UHRF1

发现和表征靶向UHRF1的Set-and-Ring结构域的尿嘧啶衍生物

Akrani, Ifigeneia; Driva, Danai; Tsakalidis, Efstratios; Mozumdar, Nandini; Mavridi, Danai; Panara, Anthi; Epiphaniou, Kalypso; Chalkiadaki, Maria; Wright, Andreanna Frances; Halabalaki, Maria; Tsoka, Angeliki; Zoidis, Grigoris; Vorgias, Constantinos; Sproul, Duncan; Gikas, Evangelos; Kriaucionis, Skirmantas; Mikros, Emmanuel; Myrianthopoulos, Vassilios

Using human disease mutations to understand de novo DNA methyltransferase function

利用人类疾病突变来了解新生DNA甲基转移酶的功能

Rolls, Willow; Wilson, Marcus D; Sproul, Duncan

Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair

由DNA修复缺陷引起的孟德尔癌症综合征家族中的种系新生突变

Sherwood, Kitty; Ward, Joseph C; Soriano, Ignacio; Martin, Lynn; Campbell, Archie; Rahbari, Raheleh; Kafetzopoulos, Ioannis; Sproul, Duncan; Green, Andrew; Sampson, Julian R; Donaldson, Alan; Ong, Kai-Ren; Heinimann, Karl; Nielsen, Maartje; Thomas, Huw; Latchford, Andrew; Palles, Claire; Tomlinson, Ian

Author Correction: Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair

作者更正:由DNA修复缺陷引起的孟德尔癌症综合征家族中的种系新生突变

Sherwood, Kitty; Ward, Joseph C; Soriano, Ignacio; Martin, Lynn; Campbell, Archie; Rahbari, Raheleh; Kafetzopoulos, Ioannis; Sproul, Duncan; Green, Andrew; Sampson, Julian R; Donaldson, Alan; Ong, Kai-Ren; Heinimann, Karl; Nielsen, Maartje; Thomas, Huw; Latchford, Andrew; Palles, Claire; Tomlinson, Ian

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation

对长读长DNA甲基化的全基因组单分子分析揭示了异染色质中反映核小体组织的异质性模式。

Kerr, Lyndsay; Kafetzopoulos, Ioannis; Grima, Ramon; Sproul, Duncan

In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

体内患者遗传异质性建模揭示胆管癌治疗的新途径

Younger, Nicholas T; Wilson, Mollie L; Martinez Lyons, Anabel; Jarman, Edward J; Meynert, Alison M; Grimes, Graeme R; Gournopanos, Konstantinos; Waddell, Scott H; Tennant, Peter A; Wilson, David H; Guest, Rachel V; Wigmore, Stephen J; Acosta, Juan Carlos; Kendall, Timothy J; Taylor, Martin S; Sproul, Duncan; Mill, Pleasantine; Boulter, Luke

Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

局部CpG密度影响与年龄相关的DNA甲基化变化的轨迹和变异性。

Higham, Jonathan; Kerr, Lyndsay; Zhang, Qian; Walker, Rosie M; Harris, Sarah E; Howard, David M; Hawkins, Emma L; Sandu, Anca-Larisa; Steele, J Douglas; Waiter, Gordon D; Murray, Alison D; Evans, Kathryn L; McIntosh, Andrew M; Visscher, Peter M; Deary, Ian J; Cox, Simon R; Sproul, Duncan