日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing

MK-8527 是一种新型的 HIV-1 逆转录酶易位抑制剂,具有延长给药时间的潜力。

Raheem, Izzat T; Girijavallabhan, Vinay; Fillgrove, Kerry L; Goh, Shih Lin; Bahnck-Teets, Carolyn; Huang, Qian; Li, Fangbiao; Wan, Bang-Lin; O'Donnell, Gregory T; Patteson, Jonathan B; Cilento, Maria E; Bennet, Amrith; Hayes, Robert P; Tummala, Srivanya; McHale, Carolyn; Wiltsie, Judyann; Ellis, Joan; Asante-Appiah, Ernest; Hazuda, Daria J; Hale, Jeffrey; Grobler, Jay A; Xu, Min; Diamond, Tracy L; Lai, Ming-Tain

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

活性状态的食欲素受体 2 的结构使肽和小分子激动剂识别和受体活化合理化

Chuan Hong #, Noel J Byrne #, Beata Zamlynny, Srivanya Tummala, Li Xiao, Jennifer M Shipman, Andrea T Partridge, Christina Minnick, Michael J Breslin, Michael T Rudd, Shawn J Stachel, Vanessa L Rada, Jeffrey C Kern, Kira A Armacost, Scott A Hollingsworth, Julie A O'Brien, Dawn L Hall, Terrence P McD

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

非活性位点 TrkA 选择性激酶抑制剂的结构表征

Hua-Poo Su, Keith Rickert, Christine Burlein, Kartik Narayan, Marina Bukhtiyarova, Danielle M Hurzy, Craig A Stump, Xufang Zhang, John Reid, Alicja Krasowska-Zoladek, Srivanya Tummala, Jennifer M Shipman, Maria Kornienko, Peter A Lemaire, Daniel Krosky, Amanda Heller, Abdelghani Achab, Chad Chamberl

Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer

与核苷酸反应产物结合的细菌脱乙酰酶 LpxC 的结构揭示了氧阴离子稳定和质子转移的机制

Gina M Clayton, Daniel J Klein, Keith W Rickert, Sangita B Patel, Maria Kornienko, Joan Zugay-Murphy, John C Reid, Srivanya Tummala, Sujata Sharma, Sheo B Singh, Lynn Miesel, Kevin J Lumb, Stephen M Soisson