日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity

分区多基因评分显示2型糖尿病和高血压合并症的机制异质性

Pascat, Vincent; Zudina, Liudmila; Maurin, Lucas; Ulrich, Anna; Maina, Jared G; Demirkan, Ayse; Balkhiyarova, Zhanna; Pupko, Igor; Sharhorodska, Yevheniya; Pattou, François; Staels, Bart; Kaakinen, Marika; Khamis, Amna; Bonnefond, Amélie; Munroe, Patricia; Froguel, Philippe; Prokopenko, Inga

Iron deficiency induces maturation-dependent loss of pancreatic β-cells.

缺铁会导致胰腺β细胞成熟依赖性丢失。

Van Mulders Annelore, Willems Lien, Coenen Sophie, Bourgeois Stephanie, Yi Xiaoyan, Tong Yue, Leuckx Gunter, Heremans Yves, Pierreux Julie, Degroote Laure, Sawatani Toshiaki, Vinci Chiara, Ates Gamze, Massie Ann, Carlotti Françoise, de Koning Eelco, Mandrup-Poulsen Thomas, Zelinsky Clara, Goderis Steven, Ghesquière Bart, Scharfmann Raphael, Cnop Miriam, De Leu Nico, Staels Willem

Transient ER stress cell-autonomously promotes beta cell cycling in mice

瞬时内质网应激以细胞自主的方式促进小鼠β细胞周期。

Bourgeois, Stephanie; Van Mulders, Annelore; Heremans, Yves; Leuckx, Gunter; Willems, Lien; Coenen, Sophie; Degroote, Laure; Pierreux, Julie; Kancheva, Daliya; Scheyltjens, Isabelle; Movahedi, Kiavash; Carlotti, Françoise; de Koning, Eelco; Yi, Xiaoyan; Vinci, Chiara; Tong, Yue; Cnop, Miriam; Heimberg, Harry; De Leu, Nico; Staels, Willem

Liver Metabolomic Profiling Reveals Distinct Signatures Between Steatosis and Metabolic Dysfunction-Associated Steatohepatitis

肝脏代谢组学分析揭示了脂肪变性和代谢功能障碍相关性脂肪性肝炎之间的独特特征

Palomurto, Saana; Flam, Emily; Kaminska, Dorota; Virtanen, Kirsi A; Kärjä, Vesa; Käkelä, Pirjo; Pajukanta, Päivi; Eberlé, Delphine; Haas, Joel T; Raverdy, Violeta; Caiazzo, Robert; Pattou, François; Staels, Bart; Pihlajamäki, Jussi; Männistö, Ville

Metabolic, enterohepatic and gut microbial effects of atorvastatin in healthy men

阿托伐他汀对健康男性代谢、肠肝功能和肠道微生物的影响

Thomasen, Martin; Misiakou, Maria-Anna; Li, Simone S; Rodriguez de Evgrafov, Mari Cristina; Lynggaard, Mads B; Kårhus, Martin L; Brønden, Andreas; Kornholt, Jonatan; Chávez-Talavera, Oscar; Tailleux, Anne; Staels, Bart; Descat, Amandine; Hartmann, Bolette; Wewer Albrechtsen, Nicolai J; Rehfeld, Jens F; Holst, Jens J; Vilsbøll, Tina; Ellegaard, Anne-Marie; Sommer, Morten O A; Sonne, David P; Knop, Filip K

LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode

LIBX-A401:一种新型选择性酰基辅酶A合成酶长链家族成员4 (ACSL4) 抑制剂及其结合模式

Mazhari Dorooee, Darius; Ravez, Séverine; Vertommen, Didier; Renault, Nicolas; Papadopoulos, Nicolas; Marteau, Romain; Charnelle, Emeline; Porte, Karine; Gobert, Alexandre; Hennuyer, Nathalie; Herinckx, Gaetan; Pautric, Maëla; Jonneaux, Aurélie; Devedjian, Jean Christophe; Devos, David; Staels, Bart; Melnyk, Patricia; Constantinescu, Stefan N; Frédérick, Raphaël; El Bakali, Jamal

Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation.

Sirtuin-1 直接结合并使肝脏 PCSK9 去乙酰化,从而促进抑制 LDL 受体降解

Velagapudi Srividya, Miranda Melroy X, Adla Priyanka, Kraler Simon, Mohammed Shafeeq A, Baki Shekhar, Robert Jerome, Rohrer Lucia, Lee Hwan, Jang Hyun-Duk, Obeid Slayman, Tailleux Anne, Staels Bart, Sepuri Naresh Babu V, Paneni Francesco, Gutti Ravi Kumar, von Eckardstein Arnold, Kim Hyo-Soo, Akhmedov Alexander, Camici Giovanni G, Lüscher Thomas F

Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes.

维拉帕米和低剂量抗小鼠胸腺细胞球蛋白联合疗法通过作用于β细胞和免疫轴,稳定逆转NOD小鼠近期发病的1型糖尿病。

Degroote Laure, Martens Pieter-Jan, Viaene Marijke, Heremans Yves, Leuckx Gunter, Geukens Nick, De Leu Nico, Staels Willem, Mathieu Chantal, Gysemans Conny

Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation

上皮转录因子GRHL2的去抑制促进肝细胞向胆管细胞的直接转分化

Vasseur, Ludivine; Gheeraert, Céline; Dubois-Chevalier, Julie; Very, Ninon; Guille, Loïc; Bou Saleh, Mohamed; Boulet, Clémence; Sobolewski, Cyril; Loyer, Pascal; Berthier, Alexandre; Legrand, Noémie; Corlu, Anne; Gnemmi, Viviane; Lasailly, Guillaume; Leteurtre, Emmanuelle; Galinousky, Dmitry; Bongiovanni, Antonino; Taront, Solenne; Toft, Nicolaj I; Grøntved, Lars; Tulasne, David; Furlan, Alessandro; Ntandja-Wandji, Line Carolle; Staels, Bart; Lefebvre, Philippe; Dubuquoy, Laurent; Eeckhoute, Jérôme

Expression of concern: Electrothermal patches driving the transdermal delivery of insulin

关注事项:电热贴片驱动胰岛素透皮给药

Pagneux, Quentin; Ye, Ran; Chengnan, Li; Barras, Alexandre; Hennuyer, Nathalie; Staels, Bart; Caina, D; Osses, J I Avila; Abderrahmani, Amar; Plaisance, Valérie; Pawlowski, Valérie; Boukherroub, Rabah; Melinte, Sorin; Szunerits, Sabine