Extensive non-clonal CAR T-cell expansion causing fatal hyperinflammatory syndrome with immune effector cell-associated hemophagocytic lymphohistiocytosis, cytokine release syndrome, and neurotoxicity syndrome
广泛的非克隆性CAR T细胞扩增导致致命的过度炎症综合征,伴有免疫效应细胞相关的噬血细胞性淋巴组织细胞增生症、细胞因子释放综合征和神经毒性综合征。
期刊:Haematologica
影响因子:7.9
doi:10.3324/haematol.2025.288162
Riedel, Andreas; Stanger, Anna M P; Kimmich, Lucca M; Hug, Stefan; Fehn, Adrian E; Schroeder, Jan C; Besemer, Britta; Casadei, Nicolas; Demidov, German; Thapa, Prithivi Jung; Faul, Christoph; Hensen, Luca; Lengerke, Claudia; Bethge, Wolfgang
炎症
T细胞
炎症/感染
T细胞
细胞生物学
毒理研究
免疫/内分泌