日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small molecule PKCε inhibitor reduces hyperalgesia induced by paclitaxel or opioid withdrawal

一种小分子PKCε抑制剂可减轻紫杉醇或阿片类药物戒断引起的痛觉过敏

Gregory-Flores, Adriana; Bonet, Ivan Jm; Desaivre, Stève; Levine, Jon D; McHardy, Stanton F; de Kraker, Harmannus C; Clanton, Nicholas A; LoCoco, Peter M; Russell, Nicholas M; Fleischer, Caleb; Messing, Robert O; Marinelli, Michela

Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species

开发一种对幼年、成年和耐药血吸虫均有效的新型化合物

Alwan, Sevan N; Taylor, Alexander B; McHardy, Stanton F; Cameron, Michael D; LoVerde, Philip T

Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing.

METTL3-METTL14 与 m6A 核苷酸的结构揭示了 m6A 转换和感知的见解

Qi Shan, Kumar Abhay, Chen Shuang, Zhou Shuo, Parihar Manish, Villalobos Carmen, Gupta Navom, Chan Siu-Hong, Rao Manjeet K, McHardy Stanton F, Haider Shozeb, Gupta Yogesh K

Preclinical Development of Brain Permeable ERβ Agonist for the Treatment of Glioblastoma

用于治疗胶质母细胞瘤的脑通透性 ERβ 激动剂的临床前开发

Uday P Pratap, Michael Tidwell, Henriette U Balinda, Nicholas A Clanton, Xue Yang, Suryavathi Viswanadhapalli, Gangadhara R Sareddy, Dong Liang, Huan Xie, Yidong Chen, Zhao Lai, Rajeshwar R Tekmal, Stanton F McHardy, Andrew J Brenner, Ratna K Vadlamudi

Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis

奥沙尼喹衍生物克服了吡喹酮治疗血吸虫病的局限性

Alwan, Sevan N; Taylor, Alexander B; Rhodes, Jayce; Tidwell, Michael; McHardy, Stanton F; LoVerde, Philip T

Design and development of microformulations for rapid release of small molecules and oligonucleotides

用于快速释放小分子和寡核苷酸的微制剂的设计和开发

T Brown, M Stanton, F Cros, S Cho, A Kiselyov

Inhibition of Ca(2+) entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation

辣椒素类似物CIDD-99通过抑制Ca(2+)内流来阻止口腔鳞状细胞癌细胞增殖。

Sun, Yuyang; Zboril, Emily K; De La Chapa, Jorge J; Chai, Xiufang; Da Conceicao, Viviane Nascimento; Valdez, Matthew C; McHardy, Stanton F; Gonzales, Cara B; Singh, Brij B

Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins

他莫昔芬衍生物改变逆转录酶依赖性内体管化和分选以阻断志贺毒素的逆行贩运

Andrey S Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F McHardy, Somshuvra Mukhopadhyay

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

通过迭代过程,可以生产出能杀死感染人类的主要血吸虫种类的奥沙尼喹衍生物。

Guzman, Meghan A; Rugel, Anastasia R; Tarpley, Reid S; Alwan, Sevan N; Chevalier, Frédéric D; Kovalskyy, Dmytro P; Cao, Xiaohang; Holloway, Stephen P; Anderson, Timothy J C; Taylor, Alexander B; McHardy, Stanton F; LoVerde, Philip T

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

小分子烟酰胺N-甲基转移酶抑制剂激活衰老肌肉干细胞,提高衰老骨骼肌的再生能力

Harshini Neelakantan, Camille R Brightwell, Ted G Graber, Rosario Maroto, Hua-Yu Leo Wang, Stanton F McHardy, John Papaconstantinou, Christopher S Fry, Stanley J Watowich