日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for pseudokinase-mediated regulation of GCN2 in the integrated stress response

假激酶介导的GCN2在整合应激反应中的调控的结构基础

Liu, Yixin; Misra, Jagannath; Bhowmik, Debarshi Ryan; O'Boyle, Brady; Staschke, Kirk A; Kannan, Natarajan; Wek, Ronald C; Jura, Natalia

PERK protein kinase facilitates keratinocyte collective cell migration by engagement with cell adhesion molecules, independent of its kinase activity

PERK蛋白激酶通过与细胞黏附分子结合,促进角质形成细胞的集体迁移,而这一过程与其激酶活性无关。

Diaz, Miguel Barriera; Staschke, Kirk A; Baucum, Anthony J 2nd; Spandau, Dan F; Wek, Ronald C

Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response

冷冻电镜揭示了ASX-173如何抑制人天冬酰胺合成酶以激活整合应激反应。

Staschke, Kirk A; Walda, Nicholas T; Pearce, Lucciano A; Wek, Ronald C; Zhu, Wen; Takagi, Yuichiro

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

eIF2 激酶 GCN2 与 p53 信号之间的协调支持嘌呤代谢和前列腺癌的进展

Ricardo A Cordova, Noah R Sommers, Andrew S Law, Angela J Klunk, Katherine E Brady, David W Goodrich, Tracy G Anthony, Jeffrey J Brault, Roberto Pili, Ronald C Wek, Kirk A Staschke

PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors

HC-5404 抑制 PERK 可增强肾细胞癌肿瘤模型对抗血管生成酪氨酸激酶抑制剂的敏感性

Michael E Stokes #, Veronica Calvo #, Sho Fujisawa, Crissy Dudgeon, Sharon Huang, Nupur Ballal, Leyi Shen, Jennifer Gasparek, Matthew Betzenhauser, Simon J Taylor, Kirk A Staschke, Alan C Rigby, Mark J Mulvihill, Nandita Bose, Eric S Lightcap, David Surguladze

A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells

PERK 特异性抑制剂通过限制静止癌细胞的综合应激反应依赖性存活来阻止转移进展

Veronica Calvo #, Wei Zheng #, Anna Adam-Artigues #, Kirk A Staschke, Xin Huang, Julie F Cheung, Ana Rita Nobre, Sho Fujisawa, David Liu, Maria Fumagalli, David Surguladze, Michael E Stokes, Ari Nowacek, Mark Mulvihill, Eduardo F Farias #, Julio A Aguirre-Ghiso

Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response

应对压力:转化控制与整合应激反应

Wek, Ronald C; Anthony, Tracy G; Staschke, Kirk A

Obtaining Functional Proteomics Insights From Thermal Proteome Profiling Through Optimized Melt Shift Calculation and Statistical Analysis With InflectSSP

通过使用 InflectSSP 优化熔解位移计算和统计分析,从热蛋白质组分析中获取功能蛋白质组学见解

Neil A McCracken, Hao Liu, Avery M Runnebohm, H R Sagara Wijeratne, Aruna B Wijeratne, Kirk A Staschke, Amber L Mosley

GCN2 is required to maintain core body temperature in mice during acute cold

GCN2 是小鼠在急性寒冷期间维持核心体温所必需的

Jordan L Levy, Emily T Mirek, Esther M Rodriguez, Brian Zalma, Jeffrey Burns, William O Jonsson, Harini Sampath, Kirk A Staschke, Ronald C Wek, Tracy G Anthony

Activation of Gcn2 by small molecules designed to be inhibitors

通过设计为抑制剂的小分子激活 Gcn2

Kenneth R Carlson, Millie M Georgiadis, Feven Tameire, Kirk A Staschke, Ronald C Wek