日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells

强效且选择性的 SETDB1 共价负变构调节剂可降低细胞中的甲基转移酶活性

Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M Szewczyk, Ka Yang, Yani Zhao, Michael A Stashko, Jacqueline L Norris-Drouin, Jarod M Waybright, Serap Beldar, Justin M Rectenwald, Angie L Mordant, Thomas S Webb, Laura E Herring, Cheryl H Arrowsmith, Suzanne Ackloo, S

UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor

UNC9426,一种强效且口服生物利用度高的TYRO3特异性抑制剂

Deyu Kong ,Xiangbo Yang ,Samantha Judd ,Dan Yan ,Stephanie Springborn ,Michael A Stashko ,Adam Kidwell ,Justus M Huelse ,Dmitri Kireev ,Douglas K Graham ,Deborah DeRyckere ,Brian Branchford ,Xiaodong Wang

Discovery of Novel TYRO3/MERTK Dual Inhibitors

新型TYRO3/MERTK双重抑制剂的发现

Deyu Kong ,Jichen Zhao ,Daowei Huang ,Michael A Stashko ,Dan Yan ,Ransheng Ding ,Shiva K R Guduru ,Yubai Zhou ,Catherine E Kania ,H Shelton Earp 3rd ,Stephen V Frye ,Justus M Huelse ,Dmitri Kireev ,Deborah DeRyckere ,Douglas K Graham ,Xiaodong Wang

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

一种用于单分子追踪的高通量平台可识别药物相互作用和细胞机制。

David Trombley McSwiggen ,Helen Liu ,Ruensern Tan ,Sebastia Agramunt Puig ,Lakshmi B Akella ,Russell Berman ,Mason Bretan ,Hanzhe Chen ,Xavier Darzacq ,Kelsey Ford ,Ruth Godbey ,Eric Gonzalez ,Adi Hanuka ,Alec Heckert ,Jaclyn J Ho ,Stephanie L Johnson ,Reed Kelso ,Aaron Klammer ,Ruchira Krishnamurthy ,Jifu Li ,Kevin Lin ,Brian Margolin ,Patrick McNamara ,Laurence Meyer ,Sarah E Pierce ,Akshay Sule ,Connor Stashko ,Yangzhong Tang ,Daniel J Anderson ,Hilary P Beck

Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors

利用激酶后口袋的结构变异来调节TAM抑制剂的多药理学特性

Megan D Hopkins,Dehui Zhang,Zhilong Chen,Andrew L McIver,Justus M Huelse,Jyoti P Mahajan,Kaikai Lyu,Xiangbo Yang,Michael A Stashko,Brittany Smith,Tsz Y Yeung,H Shelton Earp,Stephen V Frye,Deborah DeRyckere,Dmitri Kireev,Douglas K Graham,Xiaodong Wang

Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development

氟化嘧啶5-甲酰胺作为MERTK靶向氟-18-PET放射性配体开发的潜在工具

Mudududdla, Ramesh; Wong, Siu Wai; Nguyen, Nghi; Xue, Lian; Stashko, Michael A; Wang, Xiaodong; Vivash, Lucy; Binder, Michele D; Ackermann, Uwe; Bozikis, Ylva E; Kilpatrick, Trevor J; Baell, Jonathan B

Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

肿瘤相关巨噬细胞通过胶原沉积和乳腺癌微环境的代谢重编程来限制CD8+ T细胞的功能。

Kevin M Tharp ,Kelly Kersten ,Ori Maller ,Greg A Timblin ,Connor Stashko ,Fernando P Canale ,Rosa E Menjivar ,Mary-Kate Hayward ,Ilona Berestjuk ,Johanna Ten Hoeve ,Bushra Samad ,Alastrair J Ironside ,Marina Pasca di Magliano ,Alexander Muir ,Roger Geiger ,Alexis J Combes ,Valerie M Weaver

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk

机械敏感性激素信号传导促进乳腺祖细胞扩增和乳腺癌风险

Jason J Northey ,Mary-Kate Hayward ,Yoshihiro Yui ,Connor Stashko ,FuiBoon Kai ,Janna K Mouw ,Dhruv Thakar ,Jonathon N Lakins ,Alastair J Ironside ,Susan Samson ,Rita A Mukhtar ,E Shelley Hwang ,Valerie M Weaver

Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.

新型大环MERTK/AXL双重抑制剂的发现

Kong Deyu, Tian Qiang, Chen Zhilong, Zheng Hongchao, Stashko Michael A, Yan Dan, Earp H Shelton, Frye Stephen V, DeRyckere Deborah, Kireev Dmitri, Graham Douglas K, Wang Xiaodong

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer

卷积神经网络 STIFMap 揭示乳腺癌中基质硬度与 EMT 之间的关联

Connor Stashko, Mary-Kate Hayward #, Jason J Northey #, Neil Pearson, Alastair J Ironside, Johnathon N Lakins, Roger Oria, Marie-Anne Goyette, Lakyn Mayo, Hege G Russnes, E Shelley Hwang, Matthew L Kutys, Kornelia Polyak, Valerie M Weaver