Stauffer Shaun R相关文献与解析，生知库 | 链接生命科学的每一步

Characterization of Hepatotropic Small Molecule Inhibitors of Hypoxia Inducible Factor Prolyl Hydroxylase in the Prevention of Oxygen-Induced Retinopathy

肝脏嗜性小分子缺氧诱导因子脯氨酰羟化酶抑制剂在预防氧诱导视网膜病变中的作用特征分析

doi:10.1021/acs.jmedchem.4c02186

Campla, Christie; Hoppe, George; Yu, Minzhong; Woda, Juliana; Peachey, Neal S; Josyula, Vara Prasad; Stauffer, Shaun R; Sears, Jonathan E

Discovery of VU0467319: an M(1) Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

VU0467319 的发现：一种进入临床试验的 M(1) 正向变构调节剂候选药物

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.4c00769

Poslunsey, Michael S; Wood, Michael R; Han, Changho; Stauffer, Shaun R; Panarese, Joseph D; Melancon, Bruce J; Engers, Julie L; Dickerson, Jonathan W; Peng, Weimin; Noetzel, Meredith J; Cho, Hyekyung P; Rodriguez, Alice L; Hopkins, Corey R; Morrison, Ryan; Crouch, Rachel D; Bridges, Thomas M; Blobaum, Anna L; Boutaud, Olivier; Daniels, J Scott; Kates, Michael J; Castelhano, Arlindo; Rook, Jerri M; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W

发表日期：2025

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Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

病毒诱导的去ISG化导致先天免疫和细胞代谢失调

期刊:

影响因子:

doi:10.1101/2025.09.08.674928

Zhu, Junji; Liu, GuanQun; Xu, Jielin; Li, Kun; Goins, Christopher M; Yu, Huaxu; Sayyad, Zuberwasim; Zhou, Yadi; White, Evangeline; Fiehn, Oliver; Stauffer, Shaun R; Cheng, Feixiong; Gack, Michaela U

MCL1 may not mediate chemoresistance.

MCL1 可能不会介导化疗耐药性

期刊:

影响因子:

doi:10.1101/2025.08.22.671824

Emhoff Kylin A, Chung Kunho, Zhang Dongmei, Willard Belinda, Chan Timothy, Jha Babal Kant, Stauffer Shaun R, Coker Jesse A, Melenhorst Jan Joseph

MCL1

发表日期：2025

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Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer.

肾癌中 SLC1A1/EAAT3 选择性抑制剂的机制和结构导向优化

期刊:

影响因子:

doi:10.1101/2025.07.03.663021

Koochaki Pooneh, Qiu Biao, Coker Jesse A, Earsley Alexander, Wang Nancy S, Romigh Todd, Goins Christopher M, Stauffer Shaun R, Boudker Olga, Chakraborty Abhishek A

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

WDR5 是胶质母细胞瘤中癌症干细胞的一种具有治疗潜力的靶点。

期刊:Genes & Development

影响因子:7.7

doi:10.1101/gad.349803.122

Mitchell, Kelly; Sprowls, Samuel A; Arora, Sonali; Shakya, Sajina; Silver, Daniel J; Goins, Christopher M; Wallace, Lisa; Roversi, Gustavo; Schafer, Rachel E; Kay, Kristen; Miller, Tyler E; Lauko, Adam; Bassett, John; Kashyap, Anjali; D'Amato Kass, Jonathan; Mulkearns-Hubert, Erin E; Johnson, Sadie; Alvarado, Joseph; Rich, Jeremy N; Holland, Eric C; Paddison, Patrick J; Patel, Anoop P; Stauffer, Shaun R; Hubert, Christopher G; Lathia, Justin D

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer

结肠癌中表观遗传干细胞维持和化疗耐药性的毒性轴

期刊:PLoS Biology

影响因子:7.2

doi:10.1371/journal.pbio.3002295

Hubert, Christopher G; Stauffer, Shaun R; Lathia, Justin D

A PAM of the α(1A)-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer's disease mouse models without effects on blood pressure

α(1A)-肾上腺素能受体的正向变构调节剂(PAM)可改善阿尔茨海默病小鼠模型的生物标志物、长时程增强作用和认知缺陷，且不影响血压。

期刊:Current Research in Pharmacology and Drug Discovery

影响因子:

doi:10.1016/j.crphar.2023.100160

Papay, Robert S; Stauffer, Shaun R; Perez, Dianne M

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL(pro))

基于结构的ML300衍生非共价抑制剂靶向严重急性呼吸综合征冠状病毒3CL蛋白酶（SARS-CoV-2 3CL(pro)）的优化

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.1c00598

Han, Sang Hoon; Goins, Christopher M; Arya, Tarun; Shin, Woo-Jin; Maw, Joshua; Hooper, Alice; Sonawane, Dhiraj P; Porter, Matthew R; Bannister, Breyanne E; Crouch, Rachel D; Lindsey, A Abigail; Lakatos, Gabriella; Martinez, Steven R; Alvarado, Joseph; Akers, Wendell S; Wang, Nancy S; Jung, Jae U; Macdonald, Jonathan D; Stauffer, Shaun R

Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability

基于片段的NSP14核酸外切酶抑制剂开发受批次间差异的影响

Characterization of Hepatotropic Small Molecule Inhibitors of Hypoxia Inducible Factor Prolyl Hydroxylase in the Prevention of Oxygen-Induced Retinopathy

肝脏嗜性小分子缺氧诱导因子脯氨酰羟化酶抑制剂在预防氧诱导视网膜病变中的作用特征分析

Discovery of VU0467319: an M(1) Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

VU0467319 的发现：一种进入临床试验的 M(1) 正向变构调节剂候选药物

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

病毒诱导的去ISG化导致先天免疫和细胞代谢失调

MCL1 may not mediate chemoresistance.

MCL1 可能不会介导化疗耐药性

Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer.

肾癌中 SLC1A1/EAAT3 选择性抑制剂的机制和结构导向优化

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

WDR5 是胶质母细胞瘤中癌症干细胞的一种具有治疗潜力的靶点。

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer

结肠癌中表观遗传干细胞维持和化疗耐药性的毒性轴

A PAM of the α(1A)-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer's disease mouse models without effects on blood pressure

α(1A)-肾上腺素能受体的正向变构调节剂(PAM)可改善阿尔茨海默病小鼠模型的生物标志物、长时程增强作用和认知缺陷，且不影响血压。

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL(pro))

基于结构的ML300衍生非共价抑制剂靶向严重急性呼吸综合征冠状病毒3CL蛋白酶（SARS-CoV-2 3CL(pro)）的优化