日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance.

在 Q175 亨廷顿病模型小鼠中抑制 mTOR 可促进神经元自噬和突变亨廷顿蛋白的清除

Stavrides Philip, Goulbourne Chris N, Peddy James, Huo Chunfeng, Rao Mala, Khetarpal Vinod, Marchionini Deanna M, Nixon Ralph A, Yang Dun-Sheng

Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain

亨廷顿病脑内自噬-溶酶体通路病理生物学

Berg, Martin J; Veeranna; Rosa, Corrinne M; Kumar, Asok; Mohan, Panaiyur S; Stavrides, Philip; Darji, Sandipkumar; Marchionini, Deanna M; Yang, Dun-Sheng; Nixon, Ralph A

Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.

早期内体衔接蛋白 APPL1 的神经元表达增加,可重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变

Jiang Ying, Sachdeva Kuldeep, Goulbourne Chris N, Berg Martin J, Peddy James, Stavrides Philip H, Pensalfini Anna, Pawlik Monika, Malampati Sandeep, Whyte Lauren, Basavarajappa Balapal S, Subbanna Shivakumar, Bleiwas Cynthia, Smiley John F, Mathews Paul M, Nixon Ralph A

Profiling lamina specific pyramidal neurons using postmortem human formalin fixed paraffin embedded frontal cortex tissue in combination with digital spatial profiling.

利用死后人类福尔马林固定石蜡包埋额叶皮层组织结合数字空间分析技术,对特定层锥体神经元进行分析

Stanisavljevic Aleksandra, Ibrahim Kyrillos W, Stavrides Philip H, Bare Christopher, Alldred Melissa J, Heguy Adriana, Nixon Ralph A, Ginsberg Stephen D

mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

在Q175亨廷顿病模型小鼠中抑制mTOR可促进神经元自噬和突变亨廷顿蛋白的清除。

Stavrides, Philip; Goulbourne, Chris N; Peddy, James; Huo, Chunfeng; Rao, Mala; Khetarpal, Vinod; Marchionini, Deanna M; Nixon, Ralph A; Yang, Dun-Sheng

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

早期内体衔接蛋白APPL1在神经元中的表达增加,会重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变。

Jiang, Ying; Sachdeva, Kuldeep; Goulbourne, Chris N; Berg, Martin J; Peddy, James; Stavrides, Philip H; Pensalfini, Anna; Pawlik, Monika; Malampati, Sandeep; Whyte, Lauren; Basavarajappa, Balapal S; Shivakumar, Subbanna; Bleiwas, Cynthia; Smiley, John F; Mathews, Paul M; Nixon, Ralph A

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

在唐氏综合征小鼠模型中,部分降低BACE1表达可阻断阿尔茨海默病相关的内体异常和胆碱能神经退行性变:APP-CTF的作用

Jiang, Ying; Rigoglioso, Andrew; Peterhoff, Corrinne M; Pawlik, Monika; Sato, Yutaka; Bleiwas, Cynthia; Stavrides, Philip; Smiley, John F; Ginsberg, Stephen D; Mathews, Paul M; Levy, Efrat; Nixon, Ralph A

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

在阿尔茨海默病 TgCRND8 小鼠模型中逆转自噬功能障碍可改善淀粉样蛋白病理和记忆缺陷

Yang Dun-Sheng, Stavrides Philip, Mohan Panaiyur S, Kaushik Susmita, Kumar Asok, Ohno Masuo, Schmidt Stephen D, Wesson Daniel, Bandyopadhyay Urmi, Jiang Ying, Pawlik Monika, Peterhoff Corrinne M, Yang Austin J, Wilson Donald A, St George-Hyslop Peter, Westaway David, Mathews Paul M, Levy Efrat, Cuervo Ana M, Nixon Ralph A

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments

磷酸酶活性下降是神经丝衰老相关过度磷酸化的基础。

Veeranna; Yang, Dun-Sheng; Lee, Ju-Hyun; Vinod, K Yaragudri; Stavrides, Philip; Amin, Niranjana D; Pant, Harish C; Nixon, Ralph A