日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.

早期内体衔接蛋白 APPL1 的神经元表达增加,可重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变

Jiang Ying, Sachdeva Kuldeep, Goulbourne Chris N, Berg Martin J, Peddy James, Stavrides Philip H, Pensalfini Anna, Pawlik Monika, Malampati Sandeep, Whyte Lauren, Basavarajappa Balapal S, Subbanna Shivakumar, Bleiwas Cynthia, Smiley John F, Mathews Paul M, Nixon Ralph A

Profiling lamina specific pyramidal neurons using postmortem human formalin fixed paraffin embedded frontal cortex tissue in combination with digital spatial profiling.

利用死后人类福尔马林固定石蜡包埋额叶皮层组织结合数字空间分析技术,对特定层锥体神经元进行分析

Stanisavljevic Aleksandra, Ibrahim Kyrillos W, Stavrides Philip H, Bare Christopher, Alldred Melissa J, Heguy Adriana, Nixon Ralph A, Ginsberg Stephen D

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

早期内体衔接蛋白APPL1在神经元中的表达增加,会重现阿尔茨海默病相关的内体和突触功能障碍以及胆碱能神经退行性变。

Jiang, Ying; Sachdeva, Kuldeep; Goulbourne, Chris N; Berg, Martin J; Peddy, James; Stavrides, Philip H; Pensalfini, Anna; Pawlik, Monika; Malampati, Sandeep; Whyte, Lauren; Basavarajappa, Balapal S; Shivakumar, Subbanna; Bleiwas, Cynthia; Smiley, John F; Mathews, Paul M; Nixon, Ralph A