日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.

PLK4 抑制剂 RP-1664 通过双重敏感性机制在神经母细胞瘤模型中表现出强大的单药疗效

Maris John, Soria-Bretones Isabel, Casás-Selves Matias, Samanta Minu, Groff David, Murray Jayne, Fletcher Jamie, Farrel Alvin, Pastor Steven, Patel Khushbu, Goodfellow Elliot Goodfellow, Li Li, Caron Cathy, Shiwram Ariya, Kim Hyeyeon, Henry Danielle, Laterreur Nancy, Bowlan Julian, Krytska Kateryna, Neuhauser Steven, Stearns Timothy, Schubert Jeffrey, Wu Jinhua, Surrey Lea, Álvarez-Quilón Alejandro, Vallée Frédéric, Nejad Parham, Schonhoft Joseph, Li Joanna, Veloso Artur, Young Jordan, Hyer Marc, Morris Stephen, Mossé Yael P, Marshall Gary, Haber Michelle, Zimmermann Michal

Lessons learned from 20 years of preclinical testing in pediatric cancers

从20年的儿科癌症临床前试验中汲取的经验教训

Smith, Malcolm A; Houghton, Peter J; Lock, Richard B; Maris, John M; Gorlick, Richard; Kurmasheva, Raushan T; Li, Xiao-Nan; Teicher, Beverly A; Chuang, Jeffrey H; Dela Cruz, Filemon S; Dyer, Michael A; Kung, Andrew L; Lloyd, Michael W; Mossé, Yael P; Stearns, Timothy M; Stewart, Elizabeth A; Bult, Carol J; Erickson, Stephen W

Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells

Oncostatin M 信号对年轻的 Dnmt3a 突变造血干细胞的转录和功能影响

Schwartz, Logan S; Young, Kira A; Stearns, Timothy M; Boyer, Nathan; Mujica, Kristina D; Trowbridge, Jennifer J

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans.

绘制小鼠和人类肿瘤免疫微环境的遗传图谱,以建立有利于抗PD-1反应的肿瘤免疫微环境

Skelly Daniel A, Graham John P, Cheng Mingshan, Furuta Mayuko, Walter Andrew, Stoklasek Thomas A, Yang Hongyuan, Stearns Timothy M, Poirion Olivier, Zhang Ji-Gang, Grassmann Jessica D S, Luo Diane, Flynn William F, Courtois Elise T, Chang Chih-Hao, Serreze David V, Menghi Francesca, Reinholdt Laura G, Liu Edison T

Mouse phenome database: curated data repository with interactive multi-population and multi-trait analyses

小鼠表型组数据库:包含交互式多群体和多性状分析的精选数据存储库

Bogue, Molly A; Ball, Robyn L; Walton, David O; Dunn, Matthew H; Kolishovski, Georgi; Berger, Alexander; Lamoureux, Anna; Grubb, Stephen C; Gerring, Matthew; Kim, Matthew; Liang, Hongping; Emerson, Jake; Stearns, Timothy; He, Hao; Mukherjee, Gaurab; Bluis, John; Davis, Sara; Desai, Sejal; Sundberg, Beth; Kadakkuzha, Beena; Kunde-Ramamoorthy, Govindarajan; Philip, Vivek M; Chesler, Elissa J

Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis

基质金属蛋白酶7表达和肺纤维化Atp8b1突变小鼠模型中的顶端上皮缺陷

Westermann-Clark, Emma; Soundararajan, Ramani; Fukumoto, Jutaro; Patil, Sahebgowda Sidramagowda; Stearns, Timothy M; Saji, Smita; Czachor, Alexander; Hernandez-Cuervo, Helena; Breitzig, Mason; Krishnamurthy, Sudarshan; Lockey, Richard F; Kolliputi, Narasaiah

Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data

小鼠表型组数据库:一个用于存储和分析精选小鼠原始表型数据的数据库和分析平台

Bogue, Molly A; Philip, Vivek M; Walton, David O; Grubb, Stephen C; Dunn, Matthew H; Kolishovski, Georgi; Emerson, Jake; Mukherjee, Gaurab; Stearns, Timothy; He, Hao; Sinha, Vinita; Kadakkuzha, Beena; Kunde-Ramamoorthy, Govindarajan; Chesler, Elissa J

Glycine supplementation extends lifespan of male and female mice.

补充甘氨酸可延长雄性和雌性小鼠的寿命

Miller Richard A, Harrison David E, Astle C Michael, Bogue Molly A, Brind Joel, Fernandez Elizabeth, Flurkey Kevin, Javors Martin, Ladiges Warren, Leeuwenburgh Christiaan, Macchiarini Francesca, Nelson James, Ryazanov Alexey G, Snyder Jessica, Stearns Timothy M, Vaughan Douglas E, Strong Randy

Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX)

影响化疗治疗的患者来源异种移植(PDX)疗效分级的因素

Malcolm, Joan E; Stearns, Timothy M; Airhart, Susan D; Graber, Joel H; Bult, Carol J

Modeling Genetic Susceptibility to Disease

疾病遗传易感性建模

Li, Qiaoli; Philip, Vivek M; Stearns, Timothy M; Bubier, Jason A; King, Benjamin L; Low, Benjamin E; Wiles, Michael V; Saeidian, Amir Hossein; Sundberg, Beth A; Uitto, Jouni; Sundberg, John P; Veith, AC; Chu, C; Moorthy, B