日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma

在眼高压性青光眼大鼠模型中,LPAR1的药理学阻断并不能提供神经保护作用

Kocherlakota, Sai; Nicol, Alan; Locri, Filippo; Stebbins, Karin J; Lorrain, Daniel S; Tribble, James R; Williams, Pete A

Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis

利用选择性、可穿透血脑屏障的拮抗剂靶向毒蕈碱M1受体,以促进多发性硬化症的髓鞘再生

Poon, Michael M; Lorrain, Kym I; Stebbins, Karin J; Edu, Geraldine C; Broadhead, Alexander R; Lorenzana, Ariana J; Roppe, Jeffrey R; Baccei, Jill M; Baccei, Christopher S; Chen, Austin C; Green, Ari J; Lorrain, Daniel S; Chan, Jonah R

Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.

发现一种可穿透血脑屏障的小分子拮抗剂,靶向 LPA1 受体,以减少多发性硬化症中的神经炎症并促进髓鞘再生

Poon Michael M, Lorrain Kym I, Stebbins Karin J, Edu Geraldine C, Broadhead Alexander R, Lorenzana Ariana O, Paulson Bryanna E, Baccei Christopher S, Roppe Jeffrey R, Schrader Thomas O, Valdez Lino J, Xiong Yifeng, Chen Austin C, Lorrain Daniel S

Discovery of PIPE-359, a Brain-Penetrant, Selective M(1) Receptor Antagonist with Robust Efficacy in Murine MOG-EAE

PIPE-359 是一种可穿透血脑屏障的选择性 M(1) 受体拮抗剂,在小鼠 MOG-EAE 模型中表现出显著疗效。

Schrader, Thomas O; Xiong, Yifeng; Lorenzana, Ariana O; Broadhead, Alexander; Stebbins, Karin J; Poon, Michael M; Baccei, Christopher; Lorrain, Daniel S