日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities

人类蛋白聚糖连接区糖基转移酶是二聚体,并表现出意想不到的特异性

Weidler, Sascha; Bundgaard, Ole; Hessefort, Markus; Rädisch, Marisa; Graf, Christopher Günther Franz; Lam, Kevin; Neubauer, Vanessa J; Eisenreich, Johanna; Köhler, Leonhard; Moremen, Kelley W; Steentoft, Catharina; Clausen, Henrik; Huang, Teng-Yi; Hung, Shang-Cheng; Steegborn, Clemens; Weyand, Michael; Unverzagt, Carlo

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes

sirtuins 中潜在的 14-3-3 结合位点揭示了扩展的磷酸化位点识别模式

Weyand, Michael; Quast, Laura; Steegborn, Clemens

Updating the Mechanism of Bicarbonate (HCO(3)(-)) Activation of Soluble Adenylyl Cyclase (sAC)

更新碳酸氢根(HCO3-)活化可溶性腺苷酸环化酶(sAC)的机制

Ferreira, Jacob; Belliveau, Hayden; Steegborn, Clemens; Buck, Jochen; Levin, Lonny R

Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization

碘甲状腺素脱碘酶 2 催化核心的结构解析及脱碘酶催化和二聚化

Towell, Holly; Braun, Doreen; Brol, Alexander; di Fonzo, Andrea; Rijntjes, Eddy; Köhrle, Josef; Schweizer, Ulrich; Steegborn, Clemens

Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development

阐明DNA编码化合物库中先导化合物的非常规结合模式,为Sirtuin 6抑制剂的开发提供了蓝图。

You, Weijie; Montoya, Alba L; Dana, Srikanta; Franzini, Raphael M; Steegborn, Clemens

On-demand male contraception via acute inhibition of soluble adenylyl cyclase

通过急性抑制可溶性腺苷酸环化酶实现男性按需避孕

Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W Myers, David J Huggins, Clemens Steegborn, Ileana C Miranda, Peter T Meinke, Jochen Buck, Lonny R Levin

Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells

新型 1,4-二氢吡啶作为 SIRT3 的特异性结合剂和激活剂,会损害细胞活力和克隆形成能力,并下调癌细胞中缺氧诱导的靶标

Clemens Zwergel, Michele Aventaggiato, Sabrina Garbo, Elisabetta Di Bello, Bruno Fassari, Beatrice Noce, Carola Castiello, Chiara Lambona, Federica Barreca, Dante Rotili, Rossella Fioravanti, Thomas Schmalz, Michael Weyand, Amelie Niedermeier, Marco Tripodi, Gianni Colotti, Clemens Steegborn, Cecili

Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation

自由能扰动引导的小分子可溶性腺苷酸环化酶抑制剂的骨架跃迁和优化

Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R; Buck, Jochen; Myers, Robert W; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T; Huggins, David J

Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein

人类免疫缺陷病毒1型Tat蛋白抑制Sirtuin 1的分子机制

Adolph, Ramona S; Beck, Eileen; Schweimer, Kristian; Di Fonzo, Andrea; Weyand, Michael; Rösch, Paul; Wöhrl, Birgitta M; Steegborn, Clemens

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates

具有慢解离速率的第二代可溶性腺苷酸环化酶 (sAC、ADCY10) 抑制剂的设计、合成及药理学评价

Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Melanie Balbach, Navpreet Kaur, Lonny R Levin, Jochen Buck, Maria Kehr, Sandrine Coquille, Joop van den Heuvel, Clemens Steegborn, Makoto Fushimi, Efrat Finkin-Groner, Robert W Myers, Stacia Kargman, Nigel J Liverton, David J Huggins, Pe