日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities

人类蛋白聚糖连接区糖基转移酶是二聚体,并表现出意想不到的特异性

Weidler, Sascha; Bundgaard, Ole; Hessefort, Markus; Rädisch, Marisa; Graf, Christopher Günther Franz; Lam, Kevin; Neubauer, Vanessa J; Eisenreich, Johanna; Köhler, Leonhard; Moremen, Kelley W; Steentoft, Catharina; Clausen, Henrik; Huang, Teng-Yi; Hung, Shang-Cheng; Steegborn, Clemens; Weyand, Michael; Unverzagt, Carlo

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes

sirtuins 中潜在的 14-3-3 结合位点揭示了扩展的磷酸化位点识别模式

Weyand, Michael; Quast, Laura; Steegborn, Clemens

Updating the Mechanism of Bicarbonate (HCO(3)(-)) Activation of Soluble Adenylyl Cyclase (sAC)

更新碳酸氢根(HCO3-)活化可溶性腺苷酸环化酶(sAC)的机制

Ferreira, Jacob; Belliveau, Hayden; Steegborn, Clemens; Buck, Jochen; Levin, Lonny R

Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization

碘甲状腺素脱碘酶 2 催化核心的结构解析及脱碘酶催化和二聚化

Towell, Holly; Braun, Doreen; Brol, Alexander; di Fonzo, Andrea; Rijntjes, Eddy; Köhrle, Josef; Schweizer, Ulrich; Steegborn, Clemens

Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development

阐明DNA编码化合物库中先导化合物的非常规结合模式,为Sirtuin 6抑制剂的开发提供了蓝图。

You, Weijie; Montoya, Alba L; Dana, Srikanta; Franzini, Raphael M; Steegborn, Clemens

Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation

自由能扰动引导的小分子可溶性腺苷酸环化酶抑制剂的骨架跃迁和优化

Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R; Buck, Jochen; Myers, Robert W; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T; Huggins, David J

Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein

人类免疫缺陷病毒1型Tat蛋白抑制Sirtuin 1的分子机制

Adolph, Ramona S; Beck, Eileen; Schweimer, Kristian; Di Fonzo, Andrea; Weyand, Michael; Rösch, Paul; Wöhrl, Birgitta M; Steegborn, Clemens

Insights into the Mechanism of Human Deiodinase 1

人类脱碘酶1作用机制的深入研究

Rodriguez-Ruiz, Alfonso; Braun, Doreen; Pflug, Simon; Brol, Alexander; Sylvester, Marc; Steegborn, Clemens; Schweizer, Ulrich

Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein

AROS蛋白调控Sirtuin 1的分子机制

Weiss, Sandra; Adolph, Ramona S; Schweimer, Kristian; DiFonzo, Andrea; Meleshin, Marat; Schutkowski, Mike; Steegborn, Clemens

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Sirt5缺失导致的代谢重编程促进Kras诱导的胰腺癌进展

Hu, Tuo; Shukla, Surendra K; Vernucci, Enza; He, Chunbo; Wang, Dezhen; King, Ryan J; Jha, Kanupriya; Siddhanta, Kasturi; Mullen, Nicholas J; Attri, Kuldeep S; Murthy, Divya; Chaika, Nina V; Thakur, Ravi; Mulder, Scott E; Pacheco, Camila G; Fu, Xiao; High, Robin R; Yu, Fang; Lazenby, Audrey; Steegborn, Clemens; Lan, Ping; Mehla, Kamiya; Rotili, Dante; Chaudhary, Sarika; Valente, Sergio; Tafani, Marco; Mai, Antonello; Auwerx, Johan; Verdin, Eric; Tuveson, David; Singh, Pankaj K