日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression

Velcrin 分子胶可诱导 PDE3A 和 SLFN12 表达较高的胶质母细胞瘤细胞凋亡

Elisa Aquilanti, Silvia Goldoni, Andrew Baker, Kristyna Kotynkova, Sawyer Andersen, Vincent Bozinov, Galen F Gao, Andrew D Cherniack, Martin Lange, Ralf Lesche, Charlotte Kopitz, Philip Lienau, Timothy A Lewis, Marine Garrido, Stefan Gradl, Henrik Seidel, Yuen-Yi Tseng, Keith L Ligon, Patrick Y Wen,

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

发现并表征 BAY-805,一种强效且选择性的泛素特异性蛋白酶 USP21 抑制剂

Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrows

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

从头嘧啶合成是IDH突变型胶质瘤的一个可靶向弱点。

Diana D Shi ,Milan R Savani ,Michael M Levitt ,Adam C Wang ,Jennifer E Endress ,Cylaina E Bird ,Joseph Buehler ,Sylwia A Stopka ,Michael S Regan ,Yu-Fen Lin ,Vinesh T Puliyappadamba ,Wenhua Gao ,Januka Khanal ,Laura Evans ,Joyce H Lee ,Lei Guo ,Yi Xiao ,Min Xu ,Bofu Huang ,Rebecca B Jennings ,Dennis M Bonal ,Misty S Martin-Sandoval ,Tammie Dang ,Lauren C Gattie ,Amy B Cameron ,Sungwoo Lee ,John M Asara ,Harley I Kornblum ,Tak W Mak ,Ryan E Looper ,Quang-De Nguyen ,Sabina Signoretti ,Stefan Gradl ,Andreas Sutter ,Michael Jeffers ,Andreas Janzer ,Mark A Lehrman ,Lauren G Zacharias ,Thomas P Mathews ,Julie-Aurore Losman ,Timothy E Richardson ,Daniel P Cahill ,Ralph J DeBerardinis ,Keith L Ligon ,Lin Xu ,Peter Ly ,Nathalie Y R Agar ,Kalil G Abdullah ,Isaac S Harris ,William G Kaelin Jr ,Samuel K McBrayer

Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

硒蛋白谷胱甘肽过氧化物酶 4 的载脂蛋白形式及其与共价结合抑制剂 ML162 的复合物的晶体结构

Dieter Moosmayer, André Hilpmann, Jutta Hoffmann, Lennart Schnirch, Katja Zimmermann, Volker Badock, Laura Furst, John K Eaton, Vasanthi S Viswanathan, Stuart L Schreiber, Stefan Gradl, Roman C Hillig

[How do generic quotas work? An analysis using HIV infection as an example]

【通用配额是如何运作的?以艾滋病毒感染为例进行分析】

Rüsenberg, Robin; Baumgarten, Axel; Mauss, Stefan; Gradl, Gabriele; Schulz, Martin; Bartmeyer, Barbara; Kollan, Christian; Schmidt, Daniel

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

使用掩蔽的腈氧化物亲电试剂对 GPX4 进行选择性共价靶向

John K Eaton, Laura Furst, Richard A Ruberto, Dieter Moosmayer, André Hilpmann, Matthew J Ryan, Katja Zimmermann, Luke L Cai, Michael Niehues, Volker Badock, Anneke Kramm, Sixun Chen, Roman C Hillig, Paul A Clemons, Stefan Gradl, Claire Montagnon, Kiel E Lazarski, Sven Christian, Besnik Bajrami, Rol