日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans

利用肝脏人源化小鼠模型揭示胆固醇脂蛋白代谢和LXR激动剂在人体内的药效学特征

Minniti, Mirko E; Pedrelli, Matteo; Vedin, Lise-Lotte; Delbès, Anne-Sophie; Denis, Raphaël G P; Öörni, Katariina; Sala, Claudia; Pirazzini, Chiara; Thiagarajan, Divya; Nurmi, Harri J; Grompe, Markus; Mills, Kevin; Garagnani, Paolo; Ellis, Ewa C S; Strom, Stephen C; Luquet, Serge H; Wilson, Elizabeth M; Bial, John; Steffensen, Knut R; Parini, Paolo

Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors.

核受体配体诱导树突状细胞表达TREM-1:分析其在肿瘤中的作用

Fontana Raffaella, Raccosta Laura, Rovati Lucrezia, Steffensen Knut R, Paniccia Aida, Jakobsson Tomas, Melloni Giulio, Bandiera Alessandro, Mangili Giorgia, Bergamini Alice, Maggioni Daniela, Doglioni Claudio, Crocchiolo Roberto, Cella Marina, Mattioli Michela, Battaglia Cristina, Colonna Marco, Russo Vincenzo

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes

LXRα可改善肥胖诱导的2型糖尿病小鼠模型的心肌葡萄糖耐量并减少心脏肥大。

Cannon, Megan V; Silljé, Herman H W; Sijbesma, Jürgen W A; Khan, Mohsin A F; Steffensen, Knut R; van Gilst, Wiek H; de Boer, Rudolf A

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

胆固醇感应肝X受体刺激小鼠发生Th2型过敏性嗜酸性粒细胞性哮喘

Smet, Muriel; Van Hoecke, Lien; De Beuckelaer, Ans; Vander Beken, Seppe; Naessens, Thomas; Vergote, Karl; Willart, Monique; Lambrecht, Bart N; Gustafsson, Jan-Åke; Steffensen, Knut R; Grooten, Johan

Cholestenoic acids regulate motor neuron survival via liver X receptors.

胆甾酸通过肝X受体调节运动神经元的存活

Theofilopoulos Spyridon, Griffiths William J, Crick Peter J, Yang Shanzheng, Meljon Anna, Ogundare Michael, Kitambi Satish Srinivas, Lockhart Andrew, Tuschl Karin, Clayton Peter T, Morris Andrew A, Martinez Adelaida, Reddy M Ashwin, Martinuzzi Andrea, Bassi Maria T, Honda Akira, Mizuochi Tatsuki, Kimura Akihiko, Nittono Hiroshi, De Michele Giuseppe, Carbone Rosa, Criscuolo Chiara, Yau Joyce L, Seckl Jonathan R, Schüle Rebecca, Schöls Ludger, Sailer Andreas W, Kuhle Jens, Fraidakis Matthew J, Gustafsson Jan-à ke, Steffensen Knut R, Björkhem Ingemar, Ernfors Patrik, Sjövall Jan, Arenas Ernest, Wang Yuqin

Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

肝脏α受体配体通过E2F介导的机制破坏乳腺癌细胞增殖

Nguyen-Vu Trang, Vedin Lise-Lotte, Liu Ka, Jonsson Philip, Lin Jean Z, Candelaria Nicholes R, Candelaria Lindsay P, Addanki Sridevi, Williams Cecilia, Gustafsson Jan-Ã ke, Steffensen Knut R, Lin Chin-Yo

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

对小鼠肝脏中肝X受体、类视黄醇X受体和过氧化物酶体增殖物激活受体α的全基因组分析揭示了广泛的结合位点共享。

Boergesen, Michael; Pedersen, Thomas Åskov; Gross, Barbara; van Heeringen, Simon J; Hagenbeek, Dik; Bindesbøll, Christian; Caron, Sandrine; Lalloyer, Fanny; Steffensen, Knut R; Nebb, Hilde I; Gustafsson, Jan-Åke; Stunnenberg, Hendrik G; Staels, Bart; Mandrup, Susanne

Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator

人NCU-G1可作为转录因子和核受体共激活因子发挥作用。

Steffensen, Knut R; Bouzga, Mariam; Skjeldal, Frode; Kasi, Cecilie; Karahasan, Almira; Matre, Vilborg; Bakke, Oddmund; Guérin, Sylvain; Eskild, Winnie

Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue

同源域辅因子与哺乳动物FTZ-F1同源物之间相互作用的功能保守性

Steffensen, Knut R; Holter, Elin; Båvner, Ann; Nilsson, Maria; Pelto-Huikko, Markku; Tomarev, Stanislav; Treuter, Eckardt