日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation

抑制USP7会破坏非经典PRC1.1复合物的稳定性,并诱导神经母细胞瘤分化。

Cmarik, Emily A; Wahi, Abhishek; Chandekar, Sayali S; Otchere, Solomon K; Sturgis, Jennifer E; Salhotra, Silvi; Basanthakumar, Allen T; Boyd, Nehemiah X; DiGiovanni, Giulia; Zhu, He; Alexe, Gabriela; Schaefer, Daniel A; Liu, Xing; Marto, Jarrod A; Buhrlage, Sara J; Stegmaier, Kimberly; Mabe, Nathaniel W

An epigenetic bifunctional that toggles between transactivation and repression

一种表观遗传双功能蛋白,可在转录激活和抑制之间切换。

Sadagopan, Ananthan; Carson, Maximilian; Zamurs, Eriks J; Srikonda, Shanivi; Weiss, Cary N; Bond, Michael J; Sodhi, Anurag; Donovan, Katherine A; Ryan, Julia K; Fischer, Eric S; Stegmaier, Kimberly; Viswanathan, Srinivas R; Ebert, Benjamin L; Gibson, William J

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

MECOM对CEBPA的抑制作用会阻断分化,从而驱动侵袭性白血病的发生。

Fleming, Travis J; Antoszewski, Mateusz; Lambo, Sander; Gundry, Michael C; Piussi, Riccardo; Wahlster, Lara; Shah, Sanjana; Reed, Fiona E; Dong, Kevin D; Paulo, Joao A; Gygi, Steven P; Mimoso, Claudia; Goldman, Seth R; Adelman, Karen; Perry, Jennifer A; Pikman, Yana; Stegmaier, Kimberly; Barrachina, Maria N; Machlus, Kellie R; Hovestadt, Volker; Arruda, Andrea; Minden, Mark D; Voit, Richard A; Sankaran, Vijay G

Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules.

利用二价小分子对尤文氏肉瘤中的融合癌蛋白 EWSR1::FLI1 进行重新连接。

Bond Michael J, Golden Ryan P, DiGiovanni Giulia, Howard Briana, Sarott Roman C, Karim Basel A, Gourisankar Sai, Alexe Gabriela, Ross Kenneth, Jones Hannah M, Dwyer Brendan G, Gray Nathanael S, Stegmaier Kimberly

Lineage dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and -independent immunotherapeutic targets

神经母细胞瘤表面组的谱系依赖性决定了肿瘤细胞状态依赖性和非依赖性的免疫治疗靶点。

Kendsersky, Nathan M; Odrobina, Michal; Mabe, Nathaniel W; Farrel, Alvin; Grossmann, Liron; Tsang, Matthew; Groff, David; Wolpaw, Adam J; Narch, Alaa; Zammarchi, Francesca; van Berkel, Patrick H; Dang, Chi V; Mossé, Yaël P; Stegmaier, Kimberly; Maris, John M

Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma

将MCL-1抑制剂与CD37靶向嵌合抗原受体T细胞相结合,是治疗T细胞淋巴瘤的有效策略。

Heavican-Foral, Tayla B; Korell, Felix; Scarfò, Irene; Wiggers, Caroline R M; B, Allen Thayakumar; Eisenbies, Zachary; Powers, Foster; Hegel, Justin; Liu, Jianlin; Kulp, Steffen; Silva, Harrison; Wu, Gongwei; Letai, Anthony; Stegmaier, Kimberly; Lohr, Jens G; Weinstock, David M; Maus, Marcela V; Knoechel, Birgit

p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma.

p300/CBP 是尤文氏肉瘤中致病增强子活性和基因表达的重要驱动因素。

Godfrey Laura C, Regalado Brandon, Schweber Sydney R, Hatton Charles, Wenge Daniela V, Wen Yanhe, Boileau Meaghan, Wessels Maria, Qi Jun, Ott Christopher J, Stegmaier Kimberly, Rivera Miguel N, Armstrong Scott A

Inflammatory signaling pathways play a role in SYK inhibitor resistant AML.

炎症信号通路在 SYK 抑制剂耐药性 AML 中发挥作用

Tausch Sarah, Villinger Christina, Alexe Gabriela, Urban Daniel J, Shen Min, Jahn Dominique, Vischedyk Jonas, Scheich Sebastian, Serve Hubert, Hall Matthew D, Stegmaier Kimberly, Oellerich Thomas, Cremer Anjali

KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma

KAT6A/B抑制剂与维甲酸具有协同作用,可增强GD2靶向免疫疗法在神经母细胞瘤中的疗效。

Weichert-Leahey, Nina; Berezovskaya, Alla; Zimmerman, Mark W; Alvarez-Calderon, Francesca; Winschel, Marlana; Salhotra, Silvi; Mabe, Nathaniel; Perez-Atayde, Antonio; Vitorino, Francisca N de L; Garcia, Benjamin; Gerdemann, Ulrike; Stegmaier, Kimberly; Durbin, Adam D; Oldridge, Derek A; Abraham, Brian J; Look, A Thomas

Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules

利用二价小分子对尤文氏肉瘤中的融合癌蛋白 EWS/FLI1 进行重新连接

Bond, Michael J; Golden, Ryan P; DiGiovanni, Giulia; Howard, Briana; Sarott, Roman C; Karim, Basel A; Gourisankar, Sai; Alexe, Gabriela; Ross, Kenneth; Gray, Nathanael S; Stegmaier, Kimberly