日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation

在小鼠结肠炎症模型中,一种pH敏感型阿片类药物未表现出镇痛耐受性。

Degro, Claudius E; Jiménez-Vargas, Nestor Nivardo; Guzman-Rodriguez, Mabel; Schincariol, Hailey; Tsang, Quentin; Reed, David E; Lomax, Alan E; Bunnett, Nigel W; Stein, Christoph; Vanner, Stephen J

Psychological risk factors and resources for low back pain intensity and back health in daily life: An ecological momentary assessment study

日常生活中影响腰痛强度和背部健康的心理风险因素和资源:一项生态瞬时评估研究

Kolodziejczak-Krupp, Karolina; Wilhelm, Lea O; Diering, Lotte-Eleonora; Zipper, Valerie; Maas, Jana; Schäfer, Thomas; Pumberger, Matthias; Schmidt, Hendrik; Stein, Christoph; Fleig, Lena

Detailed Analysis of Back Pain: A Cross-Sectional Study of Epidemiology and Previous Therapies in a German Population

背痛的详细分析:一项针对德国人群的流行病学和既往治疗的横断面研究

Hoehl, Bernhard U; Taheri, Nima; Becker, Luis Alexander; Mödl, Lukas; Schönnagel, Lukas; Stein, Christoph; Pumberger, Matthias; Schmidt, Hendrik

Physical activity and psychosocial characteristics of individuals with and without chronic low back pain in daily life: protocol for the PRIA intensive longitudinal study

日常生活中慢性腰痛患者和非慢性腰痛患者的身体活动和心理社会特征:PRIA 强化纵向研究方案

Kolodziejczak-Krupp, Karolina; Zipper, Valerie; Wilhelm, Lea O; Thiel, Lara; Stein, Christoph; Schäfer, Thomas; Pumberger, Matthias; Schmidt, Hendrik; Fleig, Lena

Effects of pH on opioid receptor activation and implications for drug design

pH值对阿片受体激活的影响及其对药物设计的意义

Stein, Christoph

Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design

模拟炎症环境下G蛋白偶联受体信号传导的改变,以推进药物设计

Thies, Arne; Sunkara, Vikram; Ray, Sourav; Wulkow, Hanna; Celik, M Özgür; Yergöz, Fatih; Schütte, Christof; Stein, Christoph; Weber, Marcus; Winkelmann, Stefanie

Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP

pH依赖性镇痛激动剂NFEPP对G蛋白活化、钙电流和阿片受体磷酸化的调节作用

Celik, Melih Özgür; Seitz, Viola; Yergöz, Fatih; Dembla, Sandeep; Blum, Nina Kathleen; Schulz, Stefan; Stein, Christoph

Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects

在酸性微环境下激活μ-阿片受体的激动剂可抑制结肠炎疼痛且无副作用

Jiménez-Vargas, Nestor Nivardo; Yu, Yang; Jensen, Dane D; Bok, Diana Daeun; Wisdom, Matthew; Latorre, Rocco; Lopez, Cintya; Jaramillo-Polanco, Josue O; Degro, Claudius; Guzman-Rodriguez, Mabel; Tsang, Quentin; Snow, Zachary; Schmidt, Brian L; Reed, David E; Lomax, Alan Edward; Margolis, Kara Gross; Stein, Christoph; Bunnett, Nigel W; Vanner, Stephen J

Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP

非甾体类镇痛药改善损伤引起的组织酸中毒可减弱 pH 依赖性阿片类激动剂 NFEPP 的镇痛作用。

Celik, Melih Ö; Negrete, Roger; Di Rosso, Riccardo; Machelska, Halina; Stein, Christoph

A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors

低pKa配体通过激活外周μ-阿片受体抑制小鼠癌症相关疼痛

Baamonde, Ana; Menéndez, Luis; González-Rodríguez, Sara; Lastra, Ana; Seitz, Viola; Stein, Christoph; Machelska, Halina