日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Charting γ-secretase substrates by explainable AI.

利用可解释人工智能绘制 α-分泌酶底物图

Breimann Stephan, Kamp Frits, Basset Gabriele, Abou-Ajram Claudia, Güner Gökhan, Yanagida Kanta, Okochi Masayasu, Müller Stephan A, Lichtenthaler Stefan F, Langosch Dieter, Frishman Dmitrij, Steiner Harald

Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

更正:在杂合子患者状态下,可通过一系列先进化合物克服侵袭性阿尔茨海默病致病早老素突变体的γ-分泌酶调节剂耐药性。

Trambauer, Johannes; Sarmiento, Rosa Maria Rodriguez; Garringer, Holly J; Salbaum, Katja; Pedro, Liliana D; Crusius, Dennis; Vidal, Ruben; Ghetti, Bernardino; Paquet, Dominik; Baumann, Karlheinz; Lindemann, Lothar; Steiner, Harald

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site

酶-底物杂合β折叠控制γ-分泌酶活性位点的几何结构和水分子的进入。

Chen, Shu-Yu; Feilen, Lukas P; Chávez-Gutiérrez, Lucía; Steiner, Harald; Zacharias, Martin

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.

不同的跨膜结构域决定了α-分泌酶亚基早老素的切割活性的特异性和效率

Schmidt Fabian C, Fitz Katja, Feilen Lukas P, Okochi Masayasu, Steiner Harald, Langosch Dieter

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease

常染色体显性遗传阿尔茨海默病运动症状的临床、病理生理和遗传特征

Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L; Noble, James M; Berman, Sarah B; Graff-Radford, Neill R; Ghetti, Bernardino; Farlow, Martin R; Chhatwal, Jasmeer; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R; Masters, Colin L; Goate, Alison; Buckles, Virginia; Fox, Nick; Rossor, Martin; Chrem, Patricio; Allegri, Ricardo; Ringman, John M; Höglinger, Günter; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C; Bateman, Randall J; Danek, Adrian; Levin, Johannes

A Thermal Flow Sensor Based on Printed Circuit Technology in Constant Temperature Mode for Various Fluids

一种基于印刷电路技术的恒温模式热流传感器,适用于多种流体

Glatzl, Thomas; Beigelbeck, Roman; Cerimovic, Samir; Steiner, Harald; Wenig, Florian; Sauter, Thilo; Treytl, Albert; Keplinger, Franz

Distortion-free measurement of electric field strength with a MEMS sensor

利用MEMS传感器实现无失真电场强度测量

Kainz, Andreas; Steiner, Harald; Schalko, Johannes; Jachimowicz, Artur; Kohl, Franz; Stifter, Michael; Beigelbeck, Roman; Keplinger, Franz; Hortschitz, Wilfried

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

最终筛选:γ-分泌酶生成致病性β-淀粉样蛋白肽

Steiner, Harald; Fukumori, Akio; Tagami, Shinji; Okochi, Masayasu

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

一种与阿尔茨海默病相关的TREM2变异发生在ADAM切割位点,并影响其脱落和吞噬功能。

Schlepckow, Kai; Kleinberger, Gernot; Fukumori, Akio; Feederle, Regina; Lichtenthaler, Stefan F; Steiner, Harald; Haass, Christian

Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.

光亲和力映射揭示 γ-分泌酶的底物募集和临床早老素突变的机制

Fukumori Akio, Steiner Harald