日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RBM20 Truncating Variants and Human Cardiomyopathy

RBM20截断变异体与人类心肌病

Floyd, Brendan J; Njoroge, Joyce N; Krysov, Vikki A; Gomes, Bruna; Murtha, Ryan; Aribeana, Chiaka; Cannie, Douglas; Smith, Eric; Paldino, Alessia; Brown, Emily E; Barth, Andreas; Ilhan, Erkan; Johnson, Renee; Wojciak, Julianne; Alkhayat, Mohamad; Graw, Sharon; Medo, Kristen; Haas, Jan; Chahal, C Anwar A; Fenzl, Kai; Steinmetz, Lars; Gollob, Michael; Ashley, Euan; Day, Sharlene; Judge, Daniel; Roberts, Jason D; Vedantham, Vasanth; Mao, Chad Y; Fatkin, Diane; Lakdawala, Neal K; Taylor, Matthew R G; Mestroni, Luisa; Saguner, Ardan M; Tayal, Upasana; Cadrin-Tourigny, Julia; Krahn, Andrew D; James, Cynthia; Dal Ferro, Matteo; Sinagra, Gianfranco; Merlo, Marco; Owens, Anjali; Reza, Nosheen; Saberi, Sara; Helms, Adam; Elliott, Perry; Meder, Benjamin; Lancaster, Megan; Parikh, Victoria N

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells

对原代人CD4+ T细胞中的变异、增强子和基因功能进行全基因组规模定位

Moonen, Dewi P I; Claringbould, Annique; Gschwind, Andreas R; Schrod, Stefan; Braunger, Jana; Feng, Claudia; Rauscher, Benedikt; Yi, Jia; Bi, Shirley Z; Matthess, Yves; Kaulich, Manuel; Acob, Ricelle A; Ayer, Aruna; Engreitz, Jesse M; Velten, Britta; Stegle, Oliver; Trynka, Gosia; Zaugg, Judith B; Schraivogel, Daniel; Steinmetz, Lars M

Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing

利用单分子长读长测序揭示人类心力衰竭中的肌节重塑

Haas, Jan; Schudy, Sarah; Rauscher, Benedikt; Muñoz Verdú, Ana; Roßkopf, Steffen; Reich, Christoph; Donmez Yalcin, Gizem; Yalcin, Abdullah; Seeger, Timon; Dieterich, Christoph; Taft, Manuel H; Freichel, Marc; Grimm, Dirk; Manstein, Dietmar; Backs, Johannes; Frey, Norbert; Steinmetz, Lars; Meder, Benjamin

Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer

利用脂质驱动的免疫代谢通路增强大网膜转移瘤患者的免疫治疗效果

Suarez-Carmona, Meggy; Hampel, Mareike; Zhang, Xin-Wen; Pöchmann, Alexandra; Grauling-Halama, Silke A; Valous, Nektarios A; Charoentong, Pornpimol; Ferber, Dyke; Wissfeld, Jannis; Höflich, Alicia; Goriely, Stanislas; Detavernier, Aurélie; Azouz, Abdulkader; Rongvaux, Anthony; Zukunft, Sven; Fleming, Ingrid; Okun, Jürgen G; Baracos, Vickie; Heikenwalder, Mathias; Zitvogel, Laurence; Xu, Xinyi; Xu, Chenqi; Volkmar, Michael; Schraivogel, Daniel; Steinmetz, Lars; Hamanishi, Junzo; Mandai, Masaki; Gaida, Matthias; Mokry, Theresa; Nattenmüller, Johanna; Sedlaczek, Oliver; Monje, Nanna; Schwab, Roxana; Hasenburg, Annette; Mavratzas, Athanasios; Boger, Regina Johanna; Marmé, Frederik; Schott, Sarah; Halama, Niels

A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics

基于 CRISPR/Cas9 的高通量单细胞转录组学增强技术

Pandey, Amitabh C; Bezney, Jon; DeAscanis, Dante; Kirsch, Ethan B; Ahmed, Farin; Crinklaw, Austin; Choudhary, Kumari Sonal; Mandala, Tony; Deason, Jeffrey; Hamidi, Jasmin S; Siddique, Azeem; Ranganathan, Sridhar; Brown, Keith; Armstrong, Jon; Head, Steven; Ordoukhanian, Phillip; Steinmetz, Lars M; Topol, Eric J

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model.

恶性疟原虫逸出破坏内皮细胞连接,并在微血管 3D 血脑屏障模型中激活 JAK-STAT 信号通路

Piatti Livia, Batzilla Alina, Nakaki Fumio, Fleckenstein Hannah, Korbmacher François, Long Rory K M, Schraivogel Daniel, Hawkins John A, Romero-Uruñuela Tais, López-Gutiérrez Borja, Sanz Sender Silvia, Schwab Yannick, Steinmetz Lars M, Sharpe James, Bernabeu Maria

A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations.

利用全基因组遗传和环境扰动构建单细胞分辨率的基因型-表型图谱

Nadal-Ribelles Mariona, Solé Carme, Díez-Villanueva Anna, Stephan-Otto Attolini Camille, Matas Yaima, Steinmetz Lars, de Nadal Eulàlia, Posas Francesc

The editable landscape of the yeast genome reveals hotspots of structural variant formation

酵母基因组的可编辑图谱揭示了结构变异形成的热点区域

Li, Shengdi; Vonesch, Sibylle C; Roy, Kevin R; Tu, Chelsea Szu; Steudle, Friederike; Nguyen, Michelle; Jann, Cosimo; Steinmetz, Lars M

The contribution of RBM20 truncating variants to human cardiomyopathy

RBM20截断变异对人类心肌病的影响

Floyd, Brendan J; Njoroge, Joyce N; Krysov, Vikki A; Gomes, Bruna; Murtha, Ryan; Aribeana, Chiaka; Cannie, Douglas; Smith, Eric; Paldino, Alessia; Brown, Emily E; Barth, Andreas; Ilhan, Erkan; Johnson, Renee; Wojciak, Julianne; Alkhayat, Mohamad; Graw, Sharon; Medo, Kristen; Haas, Jan; Chahal, C Anwar A; Fenzl, Kai; Steinmetz, Lars; Gollob, Michael; Ashley, Euan; Day, Sharlene; Judge, Daniel; Roberts, Jason; Vedantham, Vasanth; Mao, Chad Y; Fatkin, Diane; Lakdawala, Neal K; Taylor, Matthew R G; Mestroni, Luisa; Saguner, Ardan M; Tayal, Upasana; Cadrin-Tourigny, Julia; Krahn, Andrew D; James, Cynthia; Dal Ferro, Matteo; Sinagra, Gianfranco; Merlo, Marco; Owens, Anjali; Reza, Nosheen; Saberi, Sara; Helms, Adam; Elliott, Perry; Meder, Benjamin; Parikh, Victoria N

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

针对冠状动脉疾病基因位点的增强子靶向 CRISPR 筛选提示疾病风险存在共同机制。

Ramste, Markus; Weldy, Chad; Kundu, Soumya; Zhao, Quanyi; Li, Daniel; Brand, Kayla; Sharma, Disha; Ramste, Amanda; Jagoda, Evelyn; Ray, Judhajeet; Caceres, Roxanne Diaz; Galante, James; Gschwind, Andreas R; Lahtinen, Nuutti; Nguyen, Trieu; Amrute, Junedh M; Park, Chong Yong; Kim, Juyong Brian; Kaikkonen, Minna U; Stitziel, Nathan O; Steinmetz, Lars; Kundaje, Anshul; Engreitz, Jesse M; Quertermous, Thomas