日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region

拔掉 NALCN 的侧孔可发现孔区内隐藏的药物结合位点

Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua

Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

结构引导的 NaX 解锁揭示了非选择性河豚毒素敏感阳离子通道

Cameron L Noland #, Han Chow Chua #, Marc Kschonsak #, Stephanie Andrea Heusser, Nina Braun, Timothy Chang, Christine Tam, Jia Tang, Christopher P Arthur, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh0

P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

P2X2 受体亚基界面是错义变异热点,其中突变往往会增加表观 ATP 亲和力

Federica Gasparri, Debayan Sarkar, Sarune Bielickaite, Mette Homann Poulsen, Alexander Sebastian Hauser, Stephan Alexander Pless

Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5

心脏钠通道 Nav1.5 中的磷酸化与致病突变之间的功能性串扰

Iacopo Galleano, Hendrik Harms, Koushik Choudhury, Keith Khoo, Lucie Delemotte, Stephan Alexander Pless