Stephan Philipp相关文献与解析，生知库 | 链接生命科学的每一步

Müll, Maximilian; Pourmasoumi, Farzaneh; Wehrhan, Leon; Nosovska, Olena; Stephan, Philipp; Zeihe, Hannah; Vilotijevic, Ivan; Keller, Bettina G; Kries, Hajo

发表日期：2023

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Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

老年造血细胞中 Hedgehog 信号通路活性升高会导致 DNA 损伤反应减弱。

期刊:Leukemia

影响因子:13.4

doi:10.1038/s41375-019-0641-3

Scheffold, Annika; Baig, Ali H; Chen, Zhiyang; von Löhneysen, Sarah E; Becker, Friedrich; Morita, Yohei; Avila, Alush I; Groth, Marco; Lechel, André; Schmid, Florian; Kraus, Johann M; Kestler, Hans A; Stilgenbauer, Stephan; Philipp, Melanie; Burkhalter, Martin D

Hedgehog

发表日期：2020

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Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

一种构象抗体的晶体结构，该抗体可结合 tau 寡聚体并抑制阿尔茨海默病患者提取物的病理播散

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.RA120.013638

Romany Abskharon, Paul M Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenberg

Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes

与年龄相关的淀粉样β蛋白在核内体、线粒体、自噬体和溶酶体中的神经元内聚集

期刊:Journal of Alzheimers Disease

影响因子:3.4

doi:10.3233/JAD-190835

Gregory J Brewer, Robert A Herrera, Stephan Philipp, Justyna Sosna, Jorge Mauricio Reyes-Ruiz, Charles G Glabe

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

基于结构的淀粉样β蛋白核心抑制剂表明其与tau具有共同界面

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.46924

Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenberg

信号转导

发表日期：2019

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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease

早期长期服用 CSF1R 抑制剂 PLX3397 可消除小胶质细胞，并减少阿尔茨海默病 5XFAD 小鼠模型中的神经元内淀粉样蛋白、神经斑块沉积和前纤维寡聚体的积累

期刊:Molecular Neurodegeneration

影响因子:14.9

doi:10.1186/s13024-018-0244-x

Justyna Sosna, Stephan Philipp, Ricardo Albay 3rd, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M LaFerla, Charles G Glabe

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

hIAPP 纤维片段的原子结构表明紧密结合的 β 片层对细胞毒性至关重要

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.19273

Pascal Krotee, Jose A Rodriguez, Michael R Sawaya, Duilio Cascio, Francis E Reyes, Dan Shi, Johan Hattne, Brent L Nannenga, Marie E Oskarsson, Stephan Philipp, Sarah Griner, Lin Jiang, Charles G Glabe, Gunilla T Westermark, Tamir Gonen, David S Eisenberg

Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells

TRAIL 和肿瘤坏死因子介导的癌细胞坏死性凋亡信号传导的差异和相似之处

期刊:Molecular and Cellular Biology

影响因子:3.2

doi:10.1128/MCB.00941-15

Justyna Sosna, Stephan Philipp, Johaiber Fuchslocher Chico, Carina Saggau, Jürgen Fritsch, Alexandra Föll, Johannes Plenge, Christoph Arenz, Thomas Pinkert, Holger Kalthoff, Anna Trauzold, Ingo Schmitz, Stefan Schütze, Dieter Adam

Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis

高三尖杉酯碱是一种临床批准的抗白血病药物，可增强肿瘤细胞对 TRAIL 诱导的坏死性凋亡的敏感性

期刊:Cell Communication and Signaling

影响因子:8.2

doi:10.1186/s12964-015-0103-0

Stephan Philipp, Justyna Sosna, Johannes Plenge, Holger Kalthoff, Dieter Adam

Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism

全血基因表达谱可区分静脉血栓栓塞的临床表型

期刊:Thrombosis Research

影响因子:3.4

doi:10.1016/j.thromres.2015.02.003

Lewis, Deborah A; Suchindran, Sunil; Beckman, Michele G; Hooper, W Craig; Grant, Althea M; Heit, John A; Manco-Johnson, Marilyn; Moll, Stephan; Philipp, Claire S; Kenney, Kristy; De Staercke, Christine; Pyle, Meredith E; Chi, Jen-Tsan; Ortel, Thomas L

心血管

发表日期：2015

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Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S

将氟化氨基酸生物合成掺入非核糖体肽革兰氏菌素S中

Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

老年造血细胞中 Hedgehog 信号通路活性升高会导致 DNA 损伤反应减弱。

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

一种构象抗体的晶体结构，该抗体可结合 tau 寡聚体并抑制阿尔茨海默病患者提取物的病理播散

Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes

与年龄相关的淀粉样β蛋白在核内体、线粒体、自噬体和溶酶体中的神经元内聚集

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

基于结构的淀粉样β蛋白核心抑制剂表明其与tau具有共同界面

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease

早期长期服用 CSF1R 抑制剂 PLX3397 可消除小胶质细胞，并减少阿尔茨海默病 5XFAD 小鼠模型中的神经元内淀粉样蛋白、神经斑块沉积和前纤维寡聚体的积累

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

hIAPP 纤维片段的原子结构表明紧密结合的 β 片层对细胞毒性至关重要

Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells

TRAIL 和肿瘤坏死因子介导的癌细胞坏死性凋亡信号传导的差异和相似之处

Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis

高三尖杉酯碱是一种临床批准的抗白血病药物，可增强肿瘤细胞对 TRAIL 诱导的坏死性凋亡的敏感性

Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism

全血基因表达谱可区分静脉血栓栓塞的临床表型