日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

双特异性 PD1-IL2v 和抗 PD-L1 通过增强干细胞样肿瘤反应性 CD8+ T 细胞和重编程巨噬细胞来打破肿瘤免疫抵抗

Mélanie Tichet, Stephan Wullschleger, Agnieszka Chryplewicz, Nadine Fournier, Rachel Marcone, Annamaria Kauzlaric, Krisztian Homicsko, Laura Codarri Deak, Pablo Umaña, Christian Klein, Douglas Hanahan

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression

癌细胞在恶性进展过程中重现逐步分化程序

Sadegh Saghafinia #, Krisztian Homicsko, Annunziata Di Domenico, Stephan Wullschleger, Aurel Perren, Ilaria Marinoni, Giovanni Ciriello, Iacovos P Michael #, Douglas Hanahan

Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers

髓系细胞协调全身免疫抑制,削弱针对 HPV+ 癌症的免疫疗法的疗效

Gabriele Galliverti, Stephan Wullschleger, Mélanie Tichet, Dhaarini Murugan, Nadine Zangger, Wesley Horton, Alan J Korman, Lisa M Coussens, Melody A Swartz, Douglas Hanahan

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Protor-1 是 mTORC2 介导的肾脏中 SGK1 有效激活所必需的

Laura R Pearce, Eeva M Sommer, Kei Sakamoto, Stephan Wullschleger, Dario R Alessi

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis

TAPP1 和 TAPP2 适配器与 PtdIns(3,4)P2 结合在调节敲入分析确定的胰岛素敏感性中的作用

Stephan Wullschleger, David H Wasserman, Alex Gray, Kei Sakamoto, Dario R Alessi

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

Akt T 环磷酸化的适度变化如何影响肿瘤发生和胰岛素抵抗

Stephan Wullschleger, Kei Sakamoto, Lana Johnstone, Suzanne Duce, Stewart Fleming, Dario R Alessi

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

鉴定 Protor 为 mTOR 复合物-2 的新型 Rictor 结合成分

Laura R Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F M Ibrahim, Robert Gourlay, Mark A Magnuson, Dario R Alessi