日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

通过多尺度模拟揭示RAS-RAF复合物的动力学和脂质膜耦合

Carpenter, Timothy S; Aydin, Fikret; Neale, Chris; Van, Que N; Zhang, Xiaohua; Bhatia, Harsh; Sidabras, Jason W; Frank, Peter H; Georgouli, Konstantia; Tempkin, Jeremy O B; Casamayor, Violeta Burns; Gulten, Gulcin; Shrestha, Rebika; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moody, Adam; Moon, Joseph Y; Oppelstrup, Tomas; Glosli, James N; Dharuman, Gautham; Wong, Sergio; Liu, Shusen; Hengartner, Nicolas W; López, Cesar A; Nguyen, Kien; Stanley, Christopher B; Stanton, Liam G; Patel, Lara; Reddy, Tyler; Turbyville, Thomas J; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Gnanakaran, Sandrasegaram; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520,一种首创的直接共价双重抑制剂,可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

Maciag Anna E, Stice James P, Wang Bin, Sharma Alok K, Chan Albert H, Lin Ken, Singh Devansh, Dyba Marcin, Yang Yue, Setoodeh Saman, Smith Brian P, Ju Jin Hyun, Jeknic Stevan, Rabara Dana, Zhang Zuhui, Larsen Erik K, Esposito Dominic, Denson John-Paul, Ranieri Michela, Meynardie Mary, Mehdizadeh Sadaf, Alexander Patrick A, Abreu Blanco Maria, Turner David M, Xu Rui, Lightstone Felice C, Wong Kwok-Kin, Stephen Andrew G, Wang Keshi, Simanshu Dhirendra K, Sinkevicius Kerstin W, Nissley Dwight V, Wallace Eli, McCormick Frank, Beltran Pedro J

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state

体外BRAF激活实验阐明了驱动BRAF自身抑制状态解体的分子机制

Ritt, Daniel A; Durrant, David E; Drew, Matthew R; Sandin, Suzanne I; Martinez Fiesco, Juliana A; Zhang, Xiaohua; Aydin, Fikret; Carpenter, Timothy S; Scheidemantle, Grace M; D'Ippolito, Robert A; Sohn, Alexandria L; DeHart, Caroline J; Shrestha, Rebika; Snead, Kelly; Hull, Jenna; Tempkin, Jeremy O B; Yang, Yue; Lightstone, Felice C; Streitz, Frederick H; Zhang, Ping; Turbyville, Thomas J; Stephen, Andrew G; Esposito, Dominic; Ingólfsson, Helgi I; Nissley, Dwight V; Morrison, Deborah K

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

对KRAS开关II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性结合限制。

Alexander, Patrick; Chan, Albert H; Rabara, Dana; Swain, Monalisa; Larsen, Erik K; Dyba, Marcin; Chertov, Oleg; Ashraf, Mariam; Champagne, Allison; Lin, Ken; Maciag, Anna; Gillette, William K; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Stephen, Andrew G

Observation of Ras protein GTP hydrolysis and conformation change by freeze-trap serial X-ray crystallography

利用冷冻阱连续X射线晶体衍射法观察Ras蛋白GTP水解和构象变化

Shree, Shweta; McLean, Mark A; Stephen, Andrew G; Sligar, Stephen G; Kawamura, Takashi; Sakisaka, Wakako; Makino, Yoshiteru; Matsumoto, Shigeyuki; Yoshikawa, Yoko; Hasegawa, Kazuya; Shima, Fumi; Kumasaka, Takashi

Two hearts beat as one: the debate over RAS dimers continues

两颗心跳合二为一:关于RAS二聚体的争论仍在继续

Stephen, Andrew G

A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement

自上而下的蛋白质组学分析评估KRAS4B-化合物相互作用

D'Ippolito, Robert A; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R T; Scheidemantle, Grace M; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E; Stephen, Andrew G; Esposito, Dominic; McCormick, Frank; Nissley, Dwight V; DeHart, Caroline J

Author Correction: Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

作者更正:膜脂驱动膜上KRAS4b-RAF1 RBDCRD纳米簇的形成

Shrestha, Rebika; Carpenter, Timothy S; Van, Que N; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N; López, Cesar A; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K; Ingólfsson, Helgi I; Lightstone, Felice C; Stephen, Andrew G; Streitz, Frederick H; Nissley, Dwight V; Turbyville, Thomas J