日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer-testis antigen PRAME

高亲和力 T 细胞受体 ImmTAC® 双特异性有效重定向 T 细胞以杀死表达癌睾丸抗原 PRAME 的肿瘤细胞

Ana R Ribeiro, Camille Britton-Rivet, Laura Collins, Ricardo J Carreira, Sylvie Moureau, Adel Benlahrech, Sarah Stanhope, Stephen Harper, Nathaniel Liddy, Tara M Mahon, Kristina Petrovic, Mark Fife, David Depoil, Philip Addis, Nicole Bedke, Lucie Bouard, Ronan O'Dwyer, Duncan Gascoyne, Koustubh Rana

Broadening alloselectivity of T cell receptors by structure guided engineering

通过结构引导工程扩大 T 细胞受体的同种选择性

Vijaykumar Karuppiah, Dhaval Sangani, Lorraine Whaley, Robert Pengelly, Pelin Uluocak, Ricardo J Carreira, Miriam Hock, Pietro Della Cristina, Paulina Bartasun, Paula Dobrinic, Nicola Smith, Keir Barnbrook, Ross A Robinson, Stephen Harper

Tuning the potency and selectivity of ImmTAC molecules by affinity modulation

通过亲和力调节来调整 ImmTAC 分子的效力和选择性

Ian B Robertson, Rachel Mulvaney, Nele Dieckmann, Alessio Vantellini, Martina Canestraro, Francesca Amicarella, Ronan O'Dwyer, David K Cole, Stephen Harper, Omer Dushek, Peter Kirk

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

天然无毒艰难梭菌菌株可预防艰难梭菌病

Qiwen Dong, Stephen Harper, Emma McSpadden, Sophie S Son, Marie-Maude Allen, Huaiying Lin, Rita C Smith, Carolyn Metcalfe, Victoria Burgo, Che Woodson, Anitha Sundararajan, Amber Rose, Mary McMillin, David Moran, Jessica Little, Michael Mullowney, Ashley M Sidebottom, Aimee Shen, Louis-Charles Forti

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen

针对 KRASG12D 癌症新抗原的治疗性高亲和力 T 细胞受体

Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D Dukes, Nathaniel Liddy, Ma

T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4

细胞受体与人类白细胞抗原的相互作用决定了癌症睾丸抗原 MAGE-A4 的间接肽选择性

Charlotte H Coles, Catriona McMurran, Angharad Lloyd, Miriam Hock, Linda Hibbert, Marine C C Raman, Conor Hayes, Patrick Lupardus, David K Cole, Stephen Harper

Introgression of Aegilops speltoides segments in Triticum aestivum and the effect of the gametocidal genes

将粗山羊草(Aegilops speltoides)片段导入普通小麦(Triticum aestivum)及其配子体致死基因的影响

King, Julie; Grewal, Surbhi; Yang, Cai-Yun; Hubbart Edwards, Stella; Scholefield, Duncan; Ashling, Stephen; Harper, John A; Allen, Alexandra M; Edwards, Keith J; Burridge, Amanda J; King, Ian P