日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study

Ucenprubart 是一种 CD200R 激动性抗体,具有治疗炎症性皮肤病的潜力:临床前开发和 I 期临床研究

Anja Koester ,Derrick R Witcher ,Mark Lee ,Stephen J Demarest ,Scott Potter ,Katie Werle ,Scott Bauer ,Diana Ruiz ,Laurent Malherbe ,Josh Poorbaugh ,Andrew Glasebrook ,Christoph Preuss ,Gourab Datta ,Ziqiao Wang ,Jack Knorr ,David Manner ,Dipak Patel ,Carsten Schmitz ,Paul Klekotka ,Ajay Nirula

Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy

设计肿瘤选择性前药 T 细胞接合双特异性抗体,实现更安全的免疫治疗

Amelia C McCue, Stephen J Demarest, Karen J Froning, Michael J Hickey, Stephen Antonysamy, Brian Kuhlman

Generalizable design parameters for soluble T cell receptor-based T cell engagers

可溶性T细胞受体介导的T细胞衔接器的通用设计参数

Karen J Froning # ,Arlene Sereno # ,Flora Huang ,Stephen J Demarest

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics

细胞受体的计算稳定性允许与抗体配对形成双特异性抗体

Karen Froning #, Jack Maguire #, Arlene Sereno, Flora Huang, Shawn Chang, Kenneth Weichert, Anton J Frommelt, Jessica Dong, Xiufeng Wu, Heather Austin, Elaine M Conner, Jonathan R Fitchett, Aik Roy Heng, Deepa Balasubramaniam, Mark T Hilgers, Brian Kuhlman, Stephen J Demarest

Computationally Designed Bispecific Antibodies using Negative State Repertoires

利用负状态库计算设计双特异性抗体

Andrew Leaver-Fay, Karen J Froning, Shane Atwell, Hector Aldaz, Anna Pustilnik, Frances Lu, Flora Huang, Richard Yuan, Saleema Hassanali, Aaron K Chamberlain, Jonathan R Fitchett, Stephen J Demarest, Brian Kuhlman

Fab-based bispecific antibody formats with robust biophysical properties and biological activity

具有稳健生物物理特性和生物活性的基于 Fab 的双特异性抗体形式

Xiufeng Wu, Arlene J Sereno, Flora Huang, Steven M Lewis, Ricky L Lieu, Caroline Weldon, Carina Torres, Cody Fine, Micheal A Batt, Jonathan R Fitchett, Andrew L Glasebrook, Brian Kuhlman, Stephen J Demarest

Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies

IgG/TCR 嵌合体的蛋白质设计,用于双特异性抗体内 Fab 样部分的共表达

Xiufeng Wu, Arlene J Sereno, Flora Huang, Kai Zhang, Micheal Batt, Jonathan R Fitchett, Dongmei He, Heather L Rick, Elaine M Conner, Stephen J Demarest

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR

针对 TRAIL-R2 和 LTbetaR 的稳定性工程 IgG 样双特异性抗体的抗肿瘤活性

Jennifer S Michaelson, Stephen J Demarest, Brian Miller, Aldo Amatucci, William B Snyder, Xiufeng Wu, Flora Huang, Samantha Phan, Sharon Gao, Adam Doern, Graham K Farrington, Alexey Lugovskoy, Ingrid Joseph, Veronique Bailly, Xin Wang, Ellen Garber, Jeff Browning, Scott M Glaser