日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy

DUSP5介导的平滑肌细胞增殖抑制可抑制肺动脉高压和右心室肥大

Bradley S Ferguson, Sara A Wennersten, Kimberly M Demos-Davies, Marcello Rubino, Emma L Robinson, Maria A Cavasin, Matthew S Stratton, Andrew M Kidger, Tianjing Hu, Stephen M Keyse, Robert A McKnight, Robert H Lane, Eva S Nozik, Mary C M Weiser-Evans, Timothy A McKinsey

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

整合素 αvβ6 通过多种机制驱动胰腺癌,是治疗的有效靶点

Claire S Reader, Sabari Vallath, Colin W Steele, Syed Haider, Adam Brentnall, Ami Desai, Kate M Moore, Nigel B Jamieson, David Chang, Peter Bailey, Aldo Scarpa, Rita Lawlor, Claude Chelala, Stephen M Keyse, Andrew Biankin, Jennifer P Morton, Tr Jeffry Evans, Simon T Barry, Owen J Sansom, Hemant M Ko

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2

磷酸酶 DUSP2 对非典型 MAP 激酶 ERK3 和 ERK4 的调节

Maria Perander, Rania Al-Mahdi, Thomas C Jensen, Jennifer A L Nunn, Hanne Kildalsen, Bjarne Johansen, Mads Gabrielsen, Stephen M Keyse, Ole-Morten Seternes

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

双特异性磷酸酶 5 控制 ERK 信号的局部抑制、传播和转化潜力

Andrew M Kidger, Linda K Rushworth, Julia Stellzig, Jane Davidson, Christopher J Bryant, Cassidy Bayley, Edward Caddye, Tim Rogers, Stephen M Keyse, Christopher J Caunt

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

热休克因子 1 是 p38 丝裂原活化蛋白激酶的底物

Sharadha Dayalan Naidu, Calum Sutherland, Ying Zhang, Ana Risco, Laureano de la Vega, Christopher J Caunt, C James Hastie, Douglas J Lamont, Laura Torrente, Sudhir Chowdhry, Ivor J Benjamin, Stephen M Keyse, Ana Cuenda, Albena T Dinkova-Kostova

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production

MAPK 磷酸酶 Dusp9/MKP-4 在小鼠浆细胞样树突状细胞中的选择性表达及对 IFN-β 产生的调节

Magdalena Niedzielska, Faizal A M Raffi, Jurjen Tel, Sandra Muench, Katrin Jozefowski, Nour Alati, Katharina Lahl, Jörg Mages, Ulrike Billmeier, Matthias Schiemann, Uwe K Appelt, Stefan Wirtz, Tim Sparwasser, Hubertus Hochrein, Carl G Figdor, Stephen M Keyse, Roland Lang

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production

基因陷阱小鼠揭示双特异性磷酸酶 Dusp16/MKP-7 在围产期生存和调节 Toll 样受体 (TLR) 诱导的细胞因子产生中的重要作用

Magdalena Niedzielska, Barbara Bodendorfer, Sandra Münch, Alexander Eichner, Marcus Derigs, Olivia da Costa, Astrid Schweizer, Frauke Neff, Lars Nitschke, Tim Sparwasser, Stephen M Keyse, Roland Lang

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression

双特异性磷酸酶 5 通过抑制突变 Harvey-Ras (HRasQ61L) 驱动的 SerpinB2 表达来调节核 ERK 活性并抑制皮肤癌

Linda K Rushworth, Andrew M Kidger, Laurent Delavaine, Graeme Stewart, Susanne van Schelven, Jane Davidson, Christopher J Bryant, Edward Caddye, Philip East, Christopher J Caunt, Stephen M Keyse

Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif

PRAK/MK5 与非典型 MAPK ERK3 和 ERK4 对接定义了一种新型 MAPK 相互作用基序

Espen Aberg, Knut Martin Torgersen, Bjarne Johansen, Stephen M Keyse, Maria Perander, Ole-Morten Seternes

Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress

p38 丝裂原活化蛋白激酶 (MAPK) 的结合和激活在细胞应激调节 MAPK 活化蛋白激酶 5 的核质分布中起着重要作用

Ole Morten Seternes, Bjarne Johansen, Beate Hegge, Mona Johannessen, Stephen M Keyse, Ugo Moens