日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels

人类 Kv3.1 通道正调节剂的鉴定、结构和生物物理特性

Yun-Ting Chen #, Mee Ra Hong #, Xin-Jun Zhang #, James Kostas, Yuxing Li, Richard L Kraus, Vincent P Santarelli, Deping Wang, Yacob Gomez-Llorente, Alexei Brooun, Corey Strickland, Stephen M Soisson, Daniel J Klein, Anthony T Ginnetti, Michael J Marino, Shawn J Stachel, Andrii Ishchenko

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

人类白三烯B4受体1配体识别的结构见解

Nairie Michaelian,Anastasiia Sadybekov,Élie Besserer-Offroy,Gye Won Han,Harini Krishnamurthy,Beata A Zamlynny,Xavier Fradera,Phieng Siliphaivanh,Jeremy Presland,Kerrie B Spencer,Stephen M Soisson,Petr Popov,Philippe Sarret,Vsevolod Katritch,Vadim Cherezov

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

一种强效的广泛中和人类 RSV 抗体靶向融合糖蛋白的保守位点 IV

Aimin Tang, Zhifeng Chen, Kara S Cox, Hua-Poo Su, Cheryl Callahan, Arthur Fridman, Lan Zhang, Sangita B Patel, Pedro J Cejas, Ryan Swoyer, Sinoeun Touch, Michael P Citron, Dhanasekaran Govindarajan, Bin Luo, Michael Eddins, John C Reid, Stephen M Soisson, Jennifer Galli, Dai Wang, Zhiyun Wen, Gwendo

Identification of an allosteric binding site for RORγt inhibition

鉴定RORγt抑制剂的变构结合位点

Marcel Scheepstra ,Seppe Leysen ,Geert C van Almen ,J Richard Miller ,Jennifer Piesvaux ,Victoria Kutilek ,Hans van Eenennaam ,Hongjun Zhang ,Kenneth Barr ,Sunil Nagpal ,Stephen M Soisson ,Maria Kornienko ,Kristen Wiley ,Nathaniel Elsen ,Sujata Sharma ,Craig C Correll ,B Wesley Trotter ,Mario van der Stelt ,Arthur Oubrie ,Christian Ottmann ,Gopal Parthasarathy ,Luc Brunsveld

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4

蛋白偶联受体激酶 4 高血压变异 A486V 的结构和功能

Samantha J Allen, Gopal Parthasarathy, Paul L Darke, Ronald E Diehl, Rachael E Ford, Dawn L Hall, Scott A Johnson, John C Reid, Keith W Rickert, Jennifer M Shipman, Stephen M Soisson, Paul Zuck, Sanjeev K Munshi, Kevin J Lumb

Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer

与核苷酸反应产物结合的细菌脱乙酰酶 LpxC 的结构揭示了氧阴离子稳定和质子转移的机制

Gina M Clayton, Daniel J Klein, Keith W Rickert, Sangita B Patel, Maria Kornienko, Joan Zugay-Murphy, John C Reid, Srivanya Tummala, Sujata Sharma, Sheo B Singh, Lynn Miesel, Kevin J Lumb, Stephen M Soisson

Expression, purification and crystallization of human prolylcarboxypeptidase

人类脯氨酰羧肽酶的表达、纯化和结晶

Pravien D Abeywickrema, Sangita B Patel, Noel J Byrne, Ronald E Diehl, Dawn L Hall, Rachael E Ford, Keith W Rickert, John C Reid, Jennifer M Shipman, Wayne M Geissler, Kelly D Pryor, Ranabir SinhaRoy, Stephen M Soisson, Kevin J Lumb, Sujata Sharma