日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling

白细胞介素(IL)-12 和 IL-18 协同促进 MAIT 细胞产生 IL-17A 和 IL-17F,且该过程独立于 IL-23 信号通路。

Suzanne Cole ,Janine Murray ,Catherine Simpson ,Remi Okoye ,Kerry Tyson ,Meryn Griffiths ,Dominique Baeten ,Stevan Shaw ,Asher Maroof

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

Bimekizumab,一种可中和 IL-17A 和 IL-17F 的新型人源化 IgG1 抗体

Ralph Adams, Asher Maroof, Terry Baker, Alastair D G Lawson, Ruth Oliver, Ross Paveley, Steve Rapecki, Stevan Shaw, Pavan Vajjah, Shauna West, Meryn Griffiths

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells

使用 bimekizumab 双重中和 IL-17F 和 IL-17A 可阻断炎症驱动的人类骨膜细胞成骨分化

Mittal Shah, Asher Maroof, Panos Gikas, Gayatri Mittal, Richard Keen, Dominique Baeten, Stevan Shaw, Scott J Roberts

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

bimekizumab 在银屑病关节炎中对 IL-17A 和 IL-17F 的双重中和作用:临床前实验和随机安慰剂对照临床试验的证据表明 IL-17F 会导致人类慢性组织炎症

Sophie Glatt, Dominique Baeten, Terry Baker, Meryn Griffiths, Lucian Ionescu, Alastair D G Lawson, Ash Maroof, Ruth Oliver, Serghei Popa, Foteini Strimenopoulou, Pavan Vajjah, Mark I L Watling, Nataliya Yeremenko, Pierre Miossec, Stevan Shaw

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

CDP7657 是一种缺乏 Fc 结构域的抗 CD40L 抗体,可抑制 CD40L 依赖性免疫反应且不会引起血栓并发症:一项体内研究

Anthony Shock, Linda Burkly, Ian Wakefield, Christopher Peters, Ellen Garber, Janine Ferrant, Frederick R Taylor, Lihe Su, Yen-Ming Hsu, David Hutto, Ali Amirkhosravi, Todd Meyer, John Francis, Sarah Malcolm, Martyn Robinson, Derek Brown, Stevan Shaw, Roland Foulkes, Alastair Lawson, Olivier Harari,

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling

olokizumab 的发现和特性:一种靶向白细胞介素 6 并中和 gp130 信号的人源化抗体

Stevan Shaw, Tim Bourne, Chris Meier, Bruce Carrington, Rich Gelinas, Alistair Henry, Andrew Popplewell, Ralph Adams, Terry Baker, Steve Rapecki, Diane Marshall, Adrian Moore, Helen Neale, Alastair Lawson

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

OX40L 阻断可治疗关节炎,尽管会促进破骨细胞生成

Emily Gwyer Findlay, Lynett Danks, Jodie Madden, Mary M Cavanagh, Kay McNamee, Fiona McCann, Robert J Snelgrove, Stevan Shaw, Marc Feldmann, Peter Charles Taylor, Nicole J Horwood, Tracy Hussell

Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury

白细胞介素-6 在腺苷介导的肺损伤模型中促进炎症和重塑

Mesias Pedroza, Daniel J Schneider, Harry Karmouty-Quintana, Julie Coote, Stevan Shaw, Rebecca Corrigan, Jose G Molina, Joseph L Alcorn, David Galas, Richard Gelinas, Michael R Blackburn