日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

酵母 RNA 甲基化复合物由保守但重新配置的组分组成,具有依赖和不依赖 m6A 的作用

Imke Ensinck #, Alexander Maman #, Waleed S Albihlal #, Michelangelo Lassandro #, Giulia Salzano #, Theodora Sideri, Steven A Howell, Enrica Calvani, Harshil Patel, Guy Bushkin, Markus Ralser, Ambrosius P Snijders, Mark Skehel, Ana Casañal, Schraga Schwartz, Folkert J van Werven

A malaria parasite phospholipase facilitates efficient asexual blood stage egress

疟原虫磷脂酶促进无性血液阶段有效排出

Abhinay Ramaprasad, Paul-Christian Burda, Konstantinos Koussis, James A Thomas, Emma Pietsch, Enrica Calvani, Steven A Howell, James I MacRae, Ambrosius P Snijders, Tim-Wolf Gilberger, Michael J Blackman

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

对疟原虫的出走和配子发生至关重要的 Ca2+ 信号依赖于与 PKG 相互作用的多通道膜蛋白

Aurélia C Balestra, Konstantinos Koussis, Natacha Klages, Steven A Howell, Helen R Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J Perrin, Lorenzo Brusini, Patrizia Arboit, Olalla Sanz, Laura Peces-Barba Castaño, Chrislaine Withers-Martinez, Alexandre Hainard, Sonja Ghidelli-Disse, Ambrosius

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

疟疾出口蛋白酶的自催化激活可用药物治疗,并且需要蛋白质辅因子

Michele S Y Tan, Konstantinos Koussis, Chrislaine Withers-Martinez, Steven A Howell, James A Thomas, Fiona Hackett, Ellen Knuepfer, Min Shen, Matthew D Hall, Ambrosius P Snijders, Michael J Blackman

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

疟原虫脱落酶 SUB2 控制入侵时宿主红细胞膜密封

Christine R Collins #, Fiona Hackett #, Steven A Howell, Ambrosius P Snijders, Matthew Rg Russell, Lucy M Collinson, Michael J Blackman

Amide-Linked C4″-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model.

KRN7000 的酰胺连接 C4'-糖修饰可在人源化小鼠模型中有效刺激人类不变 NKT 细胞和抗肿瘤免疫

Saavedra-Avila Noemi Alejandra, Keshipeddy Santosh, Guberman-Pfeffer Matthew J, Pérez-Gallegos Ayax, Saini Neeraj K, Schäfer Carolina, Carreño Leandro J, Gascón José A, Porcelli Steven A, Howell Amy R

Depleted circulatory complement-lysis inhibitor (CLI) in childhood cerebral malaria returns to normal with convalescence

儿童脑型疟疾患者循环补体溶解抑制剂 (CLI) 耗竭,随着康复期恢复正常

Samuel Eneọjọ Abah, Florence Burté, Steven A Howell, Ikeoluwa Lagunju, Wuraola A Shokunbi, Mats Wahlgren, Olugbemiro Sodeinde, Biobele J Brown, Anthony A Holder, Delmiro Fernandez-Reyes

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

磷酸依赖性调控 SAMHD1 寡聚化,结合催化和限制

Laurence H Arnold, Harriet C T Groom, Simone Kunzelmann, David Schwefel, Sarah J Caswell, Paula Ordonez, Melanie C Mann, Sabrina Rueschenbaum, David C Goldstone, Simon Pennell, Steven A Howell, Jonathan P Stoye, Michelle Webb, Ian A Taylor, Kate N Bishop

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

合成并评价一种Th2偏向性免疫刺激糖脂OCH的酰基链不饱和类似物

Velmourougane, Geetha; Raju, Ravinder; Bricard, Gabriel; Im, Jin S; Besra, Gurdyal S; Porcelli, Steven A; Howell, Amy R

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

膜内蛋白水解介导疟原虫入侵红细胞期间关键粘附素的脱落

Rebecca A O'Donnell, Fiona Hackett, Steven A Howell, Moritz Treeck, Nicole Struck, Zita Krnajski, Chrislaine Withers-Martinez, Tim W Gilberger, Michael J Blackman