日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS

胰腺癌类器官平台鉴定出一种针对突变型KRAS的特异性抑制剂

Xiaohua Duan ,Tuo Zhang ,Lingling Feng ,Neranjan de Silva ,Benjamin Greenspun ,Xing Wang ,Jenna Moyer ,M Laura Martin ,Rohit Chandwani ,Olivier Elemento ,Steven D Leach ,Todd Evans ,Shuibing Chen ,Fong Cheng Pan

A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells

消除 TRA-1-60+/TRA-1-81+ 化学耐药癌细胞的靶向途径

Lei Tan, Xiaohua Duan, Pratyusha Mutyala, Ting Zhou, Sadaf Amin, Tuo Zhang, Brian Herbst, Gokce Askan, Tomer Itkin, Zhaoying Xiang, Fabrizio Michelassi, Michael D Lieberman, Christine A Iacobuzio-Donahue, Steven D Leach, Todd Evans, Shuibing Chen

Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system

对幼虫和成年斑马鱼远端泌尿道的分析揭示了与人类系统的同源性

Ibrahim Jubber, Duncan R Morhardt, Jonathan Griffin, Marcus G Cumberbatch, Maggie Glover, Yang Zheng, Ishtiaq Rehman, Catherine A Loynes, Syed A Hussain, Stephen A Renshaw, Steven D Leach, Vincent T Cunliffe, James W F Catto

A gene-environment-induced epigenetic program initiates tumorigenesis

基因-环境诱导的表观遗传程序启动肿瘤发生

Direna Alonso-Curbelo ,Yu-Jui Ho ,Cassandra Burdziak ,Jesper L V Maag ,John P Morris 4th ,Rohit Chandwani ,Hsuan-An Chen ,Kaloyan M Tsanov ,Francisco M Barriga ,Wei Luan ,Nilgun Tasdemir ,Geulah Livshits ,Elham Azizi ,Jaeyoung Chun ,John E Wilkinson ,Linas Mazutis ,Steven D Leach ,Richard Koche ,Dana Pe'er ,Scott W Lowe

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

胰腺腺鳞癌中 UPF1 变异的起源和后果

Jacob T Polaski, Dylan B Udy, Luisa F Escobar-Hoyos, Gokce Askan, Steven D Leach, Andrea Ventura, Ram Kannan, Robert K Bradley

Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers

SMAD 和 MAPK 信号的共同抑制可增强 BRAF 突变型甲状腺癌对 124I 的吸收

Kathleen A Luckett, Jennifer R Cracchiolo, Gnana P Krishnamoorthy, Luis Javier Leandro-Garcia, James Nagarajah, Mahesh Saqcena, Rona Lester, Soo Y Im, Zhen Zhao, Scott W Lowe, Elisa de Stanchina, Eric J Sherman, Alan L Ho, Steven D Leach, Jeffrey A Knauf, James A Fagin

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

ILC2 通过激活组织特异性癌症免疫来增强 PD-1 阻断作用

John Alec Moral, Joanne Leung #, Luis A Rojas #, Jennifer Ruan #, Julia Zhao, Zachary Sethna, Anita Ramnarain, Billel Gasmi, Murali Gururajan, David Redmond, Gokce Askan, Umesh Bhanot, Ela Elyada, Youngkyu Park, David A Tuveson, Mithat Gönen, Steven D Leach, Jedd D Wolchok, Ronald P DeMatteo, Taha M

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner

肿瘤微管以 Arp2/3 复合物依赖的方式连接胰腺癌细胞

Casey J Latario, Lori W Schoenfeld, Charles L Howarth, Laura E Pickrell, Fatema Begum, Dawn A Fischer, Olivera Grbovic-Huezo, Steven D Leach, Yolanda Sanchez, Kerrington D Smith, Henry N Higgs

α-Ketoglutarate links p53 to cell fate during tumour suppression

α-酮戊二酸在肿瘤抑制过程中将p53与细胞命运联系起来

John P Morris 4th # ,Jossie J Yashinskie # ,Richard Koche ,Rohit Chandwani ,Sha Tian ,Chi-Chao Chen ,Timour Baslan ,Zoran S Marinkovic ,Francisco J Sánchez-Rivera ,Steven D Leach ,Carlos Carmona-Fontaine ,Craig B Thompson ,Lydia W S Finley ,Scott W Lowe

EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC

EIF1AX 和 RAS 突变通过 ATF4 和 c-MYC 协同作用驱动甲状腺肿瘤发生

Gnana P Krishnamoorthy, Natalie R Davidson, Steven D Leach, Zhen Zhao, Scott W Lowe, Gina Lee, Iňigo Landa, James Nagarajah, Mahesh Saqcena, Kamini Singh, Hans-Guido Wendel, Snjezana Dogan, Prasanna P Tamarapu, John Blenis, Ronald A Ghossein, Jeffrey A Knauf, Gunnar Rätsch, James A Fagin