日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models

亚纳摩尔级MAS相关G蛋白偶联受体X2/B2拮抗剂,对人肥大细胞和疾病模型均有效

Ghazl Al Hamwi # ,Mohamad Wessam Alnouri # ,Sven Verdonck # ,Piotr Leonczak ,Shaswati Chaki ,Stefan Frischbutter ,Pavel Kolkhir ,Michaela Matthey ,Constantin Kopp ,Marek Bednarski ,Yvonne K Riedel ,Daniel Marx ,Sophie Clemens ,Vigneshwaran Namasivayam ,Susanne Gattner ,Dominik Thimm ,Katharina Sylvester ,Katharina Wolf ,Andreas E Kremer ,Steven De Jonghe ,Daniela Wenzel ,Magdalena Kotańska ,Hydar Ali ,Piet Herdewijn ,Christa E Müller

Optimization of SARS-CoV-2 Mpro Inhibitors by a Structure-Based Multilevel Virtual Screening Method

基于结构的多级虚拟筛选方法优化 SARS-CoV-2 Mpro 抑制剂

Lanlan Jing, Fabao Zhao, Lin Zheng, Bairu Meng, Shenghua Gao, Manon Laporte, Dirk Jochmans, Steven De Jonghe, Johan Neyts, Peng Zhan, Dongwei Kang, Xinyong Liu

Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells

开发细胞模型来研究肿瘤浸润调节性 T 细胞中的 CCR8 信号传导

Libao Liu, Laurie Rangan, Nathan Vanalken, Qianqian Kong, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy

Synthesis of a 3,7-Disubstituted Isothiazolo[4,3- b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase

3,7-二取代异噻唑并[4,3-b]吡啶的合成及其作为细胞周期蛋白G相关激酶的潜在抑制剂

Tom Grisez, Nitha Panikkassery Ravi, Mathy Froeyen, Dominique Schols, Luc Van Meervelt, Steven De Jonghe, Wim Dehaen

3-nitropyridine analogues as novel microtubule-targeting agents

3-硝基吡啶类似物作为新型微管靶向药物

Jean Herman, Els Vanstreels, Dorothée Bardiot, Andrea E Prota, Natacha Gaillard, Ling-Jie Gao, Thomas Vercruysse, Leentje Persoons, Tinne Daems, Mark Waer, Piet Herdewijn, Thierry Louat, Michel O Steinmetz, Steven De Jonghe, Ben Sprangers, Dirk Daelemans

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

SARS-CoV-2 3CLpro 中的 L50F、E166A 和 L167F 替换在体外被蛋白酶抑制剂选择并赋予对尼玛瑞韦的抗性

Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M Blatt, Leonid Beigelman, Julian A Symons, Pie

Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

鉴定出一种具有广谱细胞特异性活性的 Cathepsin L 抑制剂 Z-Tyr-Ala-CHN2,可对抗冠状病毒(包括 SARS-CoV-2)

Jordi Doijen, Koen Temmerman, Christel Van den Eynde, Annick Diels, Nick Van den Broeck, Michiel Van Gool, Inha Heo, Steffen Jaensch, Marleen Zwaagstra, Mayra Diosa Toro, Winston Chiu, Steven De Jonghe, Pieter Leyssen, Denisa Bojkova, Sandra Ciesek, Jindrich Cinatl, Lore Verschueren, Christophe Buyc

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

口服蛋白酶抑制剂 (PF-07321332) 可保护叙利亚仓鼠免受令人担忧的 SARS-CoV-2 变种的感染

Rana Abdelnabi, Caroline S Foo, Dirk Jochmans, Laura Vangeel, Steven De Jonghe, Patrick Augustijns, Raf Mols, Birgit Weynand, Thanaporn Wattanakul, Richard M Hoglund, Joel Tarning, Charles E Mowbray, Peter Sjö, Fanny Escudié, Ivan Scandale, Eric Chatelain, Johan Neyts

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

超大规模虚拟筛选鉴定出具有广谱抗冠状病毒活性的 SARS-CoV-2 主要蛋白酶抑制剂

Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J Craig, Yoseph Atilaw, Anja Sandström, Lindon W K Moodie, Åk

Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model

小分子激动剂刺激非典型趋化因子受体 3 (ACKR3) 可减轻临床前肝脏而非肺损伤模型中的纤维化

Tom Van Loy, Steven De Jonghe, Karolien Castermans, Wouter Dheedene, Reinout Stoop, Lars Verschuren, Matthias Versele, Patrick Chaltin, Aernout Luttun, Dominique Schols