日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

HIF 激活增强单核吞噬细胞上 FcγRIIb 的表达,阻碍肿瘤靶向抗体免疫治疗

Khiyam Hussain, Rena Liu, Rosanna C G Smith, Kri T J Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L S Cleary, Robert J Oldham, Russell B Foxall, Sonya James, Steven G Booth, Tom Murray, Lekh N Dahal, Chantal E Hargreaves, Robert S Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena

Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments

Fc 基因缺失的抗 PD-1 单克隆抗体可在不同的免疫环境中提供最佳的检查点阻断

Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, H T Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers

Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration

全身炎症加速慢性神经退行性疾病实验模型中小胶质细胞和突触标志物的变化

Joe K Chouhan, Ursula Püntener, Steven G Booth, Jessica L Teeling

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

表位特异性和同种型之间的复杂相互作用决定了抗人 CD40 抗体的生物活性

Xiaojie Yu, H T Claude Chan, Christian M Orr, Osman Dadas, Steven G Booth, Lekh N Dahal, Christine A Penfold, Lyn O'Brien, C Ian Mockridge, Ruth R French, Patrick Duriez, Leon R Douglas, Arwen R Pearson, Mark S Cragg, Ivo Tews, Martin J Glennie, Ann L White

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function

共刺激受体 4-1BB 抗体通过消耗调节性 T 细胞和促进 CD8 T 细胞效应功能来增强抗肿瘤免疫

Sarah L Buchan, Lang Dou, Marcus Remer, Steven G Booth, Stuart N Dunn, Chester Lai, Monika Semmrich, Ingrid Teige, Linda Mårtensson, Christine A Penfold, H T Claude Chan, Jane E Willoughby, C Ian Mockridge, Lekh N Dahal, Kirstie L S Cleary, Sonya James, Anne Rogel, Päivi Kannisto, Mats Jernetz, Emil

Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies

人类免疫球蛋白 G2 铰链的构象赋予免疫刺激抗癌抗体超激动剂特性

Ann L White, H T Claude Chan, Ruth R French, Jane Willoughby, C Ian Mockridge, Ali Roghanian, Christine A Penfold, Steven G Booth, Ali Dodhy, Marta E Polak, Elizabeth A Potter, Michael R Ardern-Jones, J Sjef Verbeek, Peter W M Johnson, Aymen Al-Shamkhani, Mark S Cragg, Stephen A Beers, Martin J Glen

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

全身细菌感染对脑血管和小胶质细胞的长期影响

Ursula Püntener, Steven G Booth, V Hugh Perry, Jessica L Teeling