日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof

鲁索替尼、Fedratinib 及其衍生物对 JAK2 抑制的结构洞察

Ryan R Davis, Baoli Li, Sang Y Yun, Alice Chan, Pradeep Nareddy, Steven Gunawan, Muhammad Ayaz, Harshani R Lawrence, Gary W Reuther, Nicholas J Lawrence, Ernst Schönbrunn

Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors

二氢蝶啶酮和嘧啶二氮杂卓酮激酶抑制剂对 BET 溴结构域的差异抑制

Rezaul Md Karim, Melissa J Bikowitz, Alice Chan, Jin-Yi Zhu, Dylan Grassie, Andreas Becker, Norbert Berndt, Steven Gunawan, Nicholas J Lawrence, Ernst Schönbrunn

Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

以 BRD4-HOXB13 共调控转录网络为靶点,使用溴结构域激酶抑制剂抑制转移性去势抵抗性前列腺癌

Niveditha Nerlakanti #, Jiqiang Yao #, Duy T Nguyen #, Ami K Patel #, Alexey M Eroshkin, Harshani R Lawrence, Muhammad Ayaz, Brent M Kuenzi, Neha Agarwal, Yunyun Chen, Steven Gunawan, Rezaul M Karim, Norbert Berndt, John Puskas, Anthony M Magliocco, Domenico Coppola, Jasreman Dhillon, Jingsong Zhang

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

配体介导的蛋白质降解揭示了CUL4型E3连接酶底物受体cereblon序列变体之间的功能保守性

Afua A Akuffo ,Aileen Y Alontaga ,Rainer Metcalf ,Matthew S Beatty ,Andreas Becker ,Jessica M McDaniel ,Rebecca S Hesterberg ,William E Goodheart ,Steven Gunawan ,Muhammad Ayaz ,Yan Yang ,Md Rezaul Karim ,Morgan E Orobello ,Kenyon Daniel ,Wayne Guida ,Jeffrey A Yoder ,Anjali M Rajadhyaksha ,Ernst Schönbrunn ,Harshani R Lawrence ,Nicholas J Lawrence ,Pearlie K Epling-Burnette

Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

强效双 BET 溴结构域激酶抑制剂可作为增值多靶点化学探针和癌症治疗剂

Stuart W Ember, Que T Lambert, Norbert Berndt, Steven Gunawan, Muhammad Ayaz, Marilena Tauro, Jin-Yi Zhu, Paula J Cranfill, Patricia Greninger, Conor C Lynch, Cyril H Benes, Harshani R Lawrence, Gary W Reuther, Nicholas J Lawrence, Ernst Schönbrunn

Bifunctional building blocks in the Ugi-azide condensation reaction: a general strategy toward exploration of new molecular diversity

Ugi-叠氮化物缩合反应中的双功能构建块:探索新分子多样性的总体策略

Steven Gunawan, Christopher Hulme