日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada

TRANSCENDENT(通过嵌入跨学科数据收集来评估脑震荡谱系中的神经信息学,从而推动新型疗法的研究转型):一项针对脑震荡患者的前瞻性观察性队列研究方案,该研究在加拿大学习型医疗系统脑震荡诊所网络中嵌入了比较疗效研究。

Zemek, Roger; Albrecht, Lisa M; Johnston, Sharon; Leddy, John; Ledoux, Andrée-Anne; Reed, Nick; Silverberg, Noah; Yeates, Keith; Lamoureux, Monica; Anderson, Charlotte; Barrowman, Nicholas; Beauchamp, Miriam H; Chen, Kitty; Chintoh, Araba; Cortel-LeBlanc, Achelle; Cortel-LeBlanc, Miguel; Corwin, Daniel J; Cowle, Stephanie; Dalton, Kristine; Dawson, Jennifer; Dodd, Andrew; El Emam, Khaled; Emery, Carolyn; Fox, Erin; Fuselli, Pamela; Gagnon, Isabelle J; Giza, Christopher; Hicks, Steven; Howell, David R; Kutcher, Stephen Alexander; Lalonde, Carlos; Mannix, Rebekah C; Master, Christina L; Mayer, Andrew R; Osmond, Martin H; Robillard, Rebecca; Schneider, Kathryn J; Tanuseputro, Peter; Terekhov, Ivan; Webster, Richard; Wellington, Cheryl Lea

Resolving chaperone-assisted protein folding on the ribosome at the peptide level

在肽水平上解决核糖体上分子伴侣辅助的蛋白质折叠

Thomas E Wales #, Aleksandra Pajak #, Alžběta Roeselová, Santosh Shivakumaraswamy, Steven Howell, Svend Kjær, F Ulrich Hartl, John R Engen, David Balchin

A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells

弓形虫蛋白的异三聚体复合物促进寄生虫在干扰素γ刺激的人体细胞中存活

Eloise J Lockyer, Francesca Torelli, Simon Butterworth, Ok-Ryul Song, Steven Howell, Anne Weston, Philip East, Moritz Treeck

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

USP25 促进病理性 HIF-1 驱动的代谢重编程,是胰腺癌的潜在治疗靶点

Jessica K Nelson, May Zaw Thin #, Theodore Evan #, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, Axel Behr

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

通过优化晶体片段匹配设计一种强效、选择性、可渗透脑的 Wnt 失活酶 Notum 抑制剂

Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Benjamin N Atkinson, Elliott D Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R Ruza, Svend Kjær, Steven Howell, Ambrosius P Snijders, Magda Bictas

Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets

基于活性的人类和疟原虫丝氨酸水解酶蛋白质分析以及潜在抗疟靶点的探究

Dara Davison, Steven Howell, Ambrosius P Snijders, Edgar Deu

TRF2-independent chromosome end protection during pluripotency

多能性过程中不依赖 TRF2 的染色体末端保护

Phil Ruis, David Van Ly, Valerie Borel, Georgia R Kafer, Afshan McCarthy, Steven Howell, Robert Blassberg, Ambrosius P Snijders, James Briscoe, Kathy K Niakan, Paulina Marzec, Anthony J Cesare, Simon J Boulton

Development of a fluorogenic ADAMTS-7 substrate

荧光 ADAMTS-7 底物的开发

Salvatore Santamaria, Frederic Buemi, Elisa Nuti, Doretta Cuffaro, Elena De Vita, Tiziano Tuccinardi, Armando Rossello, Steven Howell, Shahid Mehmood, Ambrosius P Snijders, Rens de Groot

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

通过奎西诺他特-组蛋白H1.0轴选择性抑制癌细胞自我更新

Cristina Morales Torres ,Mary Y Wu ,Sebastijan Hobor ,Elanor N Wainwright ,Matthew J Martin ,Harshil Patel ,William Grey ,Eva Grönroos ,Steven Howell ,Joana Carvalho ,Ambrosius P Snijders ,Michael Bustin ,Dominique Bonnet ,Paul D Smith ,Charles Swanton ,Michael Howell ,Paola Scaffidi

Characterization of neutralizing epitopes in antigenic site B of recently circulating influenza A(H3N2) viruses

近期流行的甲型流感病毒(H3N2)抗原位点 B 中和表位的表征

Kerstin Beer, Mian Dai, Steven Howell, Pramila Rijal, Alain R Townsend, Yipu Lin, Stephen A Wharton, Rodney S Daniels, John W McCauley