The succinate prodrug NV354 prevents brain lesions and late-stage motor dysfunction in mitochondrial complex I deficiency.
琥珀酸前药 NV354 可预防线粒体复合物 I 缺乏症引起的脑损伤和晚期运动功能障碍。
期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2026.114717
McManus Meagan J, Zhu Yi, Alves Cesar, Kohli Neha, Prada-Dacasa Patricia, Sanchez-Benito Laura, Sanz Elisenda, Yee Irene, Robinson Lozen, Sheldon Malkah, McHugh Walter J, Ranganathan Abhay, Meng Jennie, Duncan Nina, Grönberg Alvar, Wallace Douglas C, Piel Sarah, Karlsson Michael, Moss Steven J, Webster Lee, Hansson Magnus J, Elmér Eskil, Ehinger Johannes K, Quintana Albert, Kilbaugh Todd J
