日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

肿瘤内缺氧通过慢性激活整合应激反应转录因子ATF4促进CD8+ T细胞功能障碍

Coral Del Mar Alicea Pauneto ,Brian P Riesenberg ,Evelyn J Gandy ,Andrew S Kennedy ,Genevieve T Clutton ,Jessica W Hem ,Katie E Hurst ,Elizabeth G Hunt ,Jarred M Green ,Brian C Miller ,Steven P Angus ,Gary L Johnson ,Robert J Esther ,Jennifer L Guerriero ,Peng Gao ,David R Soto-Pantoja ,Robert L Ferris ,Jennifer L Modliszewski ,Michael F Coleman ,H Kay Chung ,J Justin Milner ,Stergios J Moschos ,R Luke Wiseman ,Jessica E Thaxton

Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression

空间基因表达谱分析揭示NF1相关周围神经鞘瘤进展的免疫致癌程序

Dana K Mitchell #,Breanne Burgess #,Emily E White,Abbi E Smith,Elizabeth A Sierra Potchanant,Henry Mang,Brooke E Hickey,Qingbo Lu,Shaomin Qian,Waylan Bessler,Xiaohong Li,Li Jiang,Kylee Brewster,Constance Temm,Andrew Horvai,Eric A Albright,Melissa L Fishel,Christine A Pratilas,Steven P Angus,D Wade Clapp,Steven D Rhodes

Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies

癌细胞激酶组的氧张力依赖性变异会影响信号通路和对靶向治疗的反应。

Adedeji K Adebayo ,Poornima Bhat-Nakshatri ,Christopher Davis ,Steven P Angus ,Cihat Erdogan ,Hongyu Gao ,Nick Green ,Brijesh Kumar ,Yunlong Liu ,Harikrishna Nakshatri

Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition

Neratinib 是一种泛 ERBB/HER 抑制剂,可恢复 PTEN 基因缺失的 BRAFV600E 黑色素瘤对 BRAF/MEK 抑制的敏感性

Evan DuBose #, Samantha M Bevill #, Dana K Mitchell, Noah Sciaky, Brian T Golitz, Shelley A H Dixon, Steven D Rhodes, James E Bear, Gary L Johnson, Steven P Angus

Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma

CDK4/6 和 ERK1/2 联合抑制可增强 NF1 相关丛状神经纤维瘤的抗肿瘤活性

Alyssa C Flint,Dana K Mitchell,Steven P Angus,Abbi E Smith,Waylan Bessler,Li Jiang,Henry Mang,Xiaohong Li,Qingbo Lu,Brooke Rodriguez,George E Sandusky,Andi R Masters,Chi Zhang,Pengtao Dang,Jenna Koenig,Gary L Johnson,Weihua Shen,Jiangang Liu,Amit Aggarwal,Gregory P Donoho,Melinda D Willard,Shripad V Bhagwat,D Wade Clapp,Steven D Rhodes

Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial

卡博替尼治疗 1 型神经纤维瘤病相关丛状神经纤维瘤:一项 2 期临床试验

Michael J Fisher #, Chie-Schin Shih #, Steven D Rhodes, Amy E Armstrong, Pamela L Wolters, Eva Dombi, Chi Zhang, Steven P Angus, Gary L Johnson, Roger J Packer, Jeffrey C Allen, Nicole J Ullrich, Stewart Goldman, David H Gutmann, Scott R Plotkin, Tena Rosser, Kent A Robertson, Brigitte C Widemann, A

FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036

TBCRC 036 中 FOXA1 和 HER2 靶向治疗的适应性反应决定因素

Steven P Angus, Timothy J Stuhlmiller, Gaurav Mehta, Samantha M Bevill, Daniel R Goulet, J Felix Olivares-Quintero, Michael P East, Maki Tanioka, Jon S Zawistowski, Darshan Singh, Noah Sciaky, Xin Chen, Xiaping He, Naim U Rashid, Lynn Chollet-Hinton, Cheng Fan, Matthew G Soloway, Patricia A Spears, 

SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2

SOX4 和 SMARCA4 通过转录激活 TGFBR2 协同调节 PI3k 信号传导

Gaurav A Mehta, Steven P Angus, Christen A Khella, Kevin Tong, Pooja Khanna, Shelley A H Dixon, Michael P Verzi, Gary L Johnson, Michael L Gatza

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

基于高内涵图像的分析和蛋白质组学分析可在人类 iPSC 衍生的谷氨酸能神经元 tau 蛋白病模型中识别出 Tau 磷酸化抑制剂

Chialin Cheng, Surya A Reis, Emily T Adams, Daniel M Fass, Steven P Angus, Timothy J Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T Wang, Debasis Patnaik, Roberta L Beauchamp, Danielle A Feldman, M Catarina Silva, Mriganka Sur, Gary L Johnson, Vijaya Ramesh, Bruce L Miller, Sally Temple, Kenn

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK

布加替尼通过抑制多种酪氨酸激酶(但不抑制 ALK)导致 NF2 缺陷型脑膜瘤和神经鞘瘤的肿瘤缩小

Long-Sheng Chang, Janet L Oblinger, Abbi E Smith, Marc Ferrer, Steven P Angus, Eric Hawley, Alejandra M Petrilli, Roberta L Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S Burns, Thomas S K Gilbert, Li Jiang, Xiao