日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells

β 链 II 和 III 中的淀粉样变性区域调节活细胞中 SOD1 的聚集和毒性

Luke McAlary, Jeremy R Nan, Clay Shyu, Mine Sher, Steven S Plotkin, Neil R Cashman

Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1

TDP-43 和 SOD1 中的色氨酸残基调节 SOD1 的交叉播种和毒性

Edward Pokrishevsky, Michéle G DuVal, Luke McAlary, Sarah Louadi, Silvia Pozzi, Andrei Roman, Steven S Plotkin, Anke Dijkstra, Jean-Pierre Julien, W Ted Allison, Neil R Cashman

Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein

合理生成针对致病型 Alpha-突触核蛋白的选择性单克隆抗体

Ebrima Gibbs, Beibei Zhao, Andrei Roman, Steven S Plotkin, Xubiao Peng, Shawn C C Hsueh, Adekunle Aina, Jing Wang, Clay Shyu, Calvin K Yip, Sung-Eun Nam, Johanne M Kaplan, Neil R Cashman

Assessment of protein inclusions in cultured cells using automated image analysis

使用自动图像分析评估培养细胞中的蛋白质内含物

Luke McAlary, Victoria K Shephard, Mine Sher, Lauren J Rice, Justin J Yerbury, Neil R Cashman, Steven S Plotkin

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

PI4K2A/PKR 溶酶体网络的治疗靶向性对于清除错误折叠的蛋白质和癌细胞存活至关重要

Apar Pataer, Bulent Ozpolat, RuPing Shao, Neil R Cashman, Steven S Plotkin, Charles E Samuel, Steven H Lin, Nashwa N Kabil, Jing Wang, Mourad Majidi, Bingliang Fang, Jack A Roth, Ara A Vaporciyan, Ignacio I Wistuba, Mien-Chie Hung, Stephen G Swisher

TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

TNF受体相关因子6与ALS相关的错误折叠超氧化物歧化酶1相互作用并促进其聚集

Sabrina Semmler,Myriam Gagné,Pranav Garg,Sarah R Pickles,Charlotte Baudouin,Emeline Hamon-Keromen,Laurie Destroismaisons,Yousra Khalfallah,Mathilde Chaineau,Elise Caron,Andrew N Bayne,Jean-François Trempe,Neil R Cashman,Alexandra T Star,Arsalan S Haqqani,Thomas M Durcan,Elizabeth M Meiering,Janice Robertson,Nathalie Grandvaux,Steven S Plotkin,Heidi M McBride,Christine Vande Velde

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease

一种针对阿尔茨海默病中淀粉样β寡聚体的合理设计的人源化抗体

Ebrima Gibbs, Judith M Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Cheryl L Wellington, Ian R Mackenzie, Steven S Plotkin, Johanne M Kaplan, Neil R Cashman

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

野生型 Cu/Zn 超氧化物歧化酶的细胞间传播错误折叠是通过外泌体依赖性和非依赖性机制发生的

Leslie I Grad, Justin J Yerbury, Bradley J Turner, William C Guest, Edward Pokrishevsky, Megan A O'Neill, Anat Yanai, Judith M Silverman, Rafaa Zeineddine, Lisa Corcoran, Janet R Kumita, Leila M Luheshi, Masoud Yousefi, Bradley M Coleman, Andrew F Hill, Steven S Plotkin, Ian R Mackenzie, Neil R Cash

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

超氧化物歧化酶1错误折叠在活细胞内的分子间传递

Leslie I Grad, Will C Guest, Anat Yanai, Edward Pokrishevsky, Megan A O'Neill, Ebrima Gibbs, Valentyna Semenchenko, Masoud Yousefi, David S Wishart, Steven S Plotkin, Neil R Cashman