日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin

新型共聚焦扫描蛋白质-蛋白质相互作用分析 (PPI-CONA) 揭示了 CC0651 的卓越选择性和特异性,CC0651 是一种小分子结合增强剂,可增强 E2 泛素结合酶 CDC34A 与泛素之间的弱相互作用

Joanna Koszela, Nhan T Pham, Steven Shave, Daniel St-Cyr, Derek F Ceccarelli, Steven Orlicky, Anne Marinier, Frank Sicheri, Mike Tyers, Manfred Auer

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

通过对细胞核大小的化学研究可以鉴定出对癌细胞系迁移和侵袭具有特异性影响的化合物

Sylvain Tollis, Andrea Rizzotto, Nhan T Pham, Sonja Koivukoski, Aishwarya Sivakumar, Steven Shave, Jan Wildenhain, Nikolaj Zuleger, Jeremy T Keys, Jayne Culley, Yijing Zheng, Jan Lammerding, Neil O Carragher, Valerie G Brunton, Leena Latonen, Manfred Auer, Mike Tyers, Eric C Schirmer

Quantitative Microdialysis: Experimental Protocol and Software for Small Molecule Protein Affinity Determination and for Exclusion of Compounds with Poor Physicochemical Properties

定量微透析:小分子蛋白质亲和力测定和排除物理化学性质较差的化合物的实验方案和软件

Steven Shave, Nhan T Pham, Connor B Śmieja, Manfred Auer

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

使用荧光共聚焦珠上分析实时追踪复杂的泛素化级联

Joanna Koszela, Nhan T Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F J Ceccarelli, Frank Sicheri, Mike Tyers, Manfred Auer

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei

布氏锥虫抗毒力发育表型的高通量化学筛选

Paula MacGregor, Alasdair Ivens, Steven Shave, Iain Collie, David Gray, Manfred Auer, Keith R Matthews